Sanofi

Thomas Huebschle

Dieter Kadereit

Matthias Schaefer

Stephanie Hachtel

Katrin Hiss

Axel Dietrich

Matthias Schafer

Andreas Gille

Paulus Wohlfart

Philip Janiak

Silke Haag-Diergarten

Bruno Poirier

Véronique Briand

Sabine Gratzer

Ashfaq Parkar

Matthias SCHÄFER

{4-[5-(3-chloro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid or a pharmaceutically acceptable salt thereof for use in the prevention or treatment of AKI (acute kidney injury). Medicament and pharmaceutical composition thereof.

{4-[5-(3-chloro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid for use in the prevention or treatment of acute kidney injury

The invention therefore relates to compounds of the formula I in which A, X, Y, R, Rand Rhave the given meanings. The compounds of the formula I are suitable, for example, for wound healing.

Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring

The invention relates to oxazolopyrimidine compounds of formula I, where A, Rand Rare defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing. 

2,5-substituted oxazolopyrimidine derivatives

Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring The invention therefore relates to compounds of the formula I in which X, Y, R, Rand Rhave the given meanings. The compounds of the formula I are suitable, for example, for wound healing.

Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring

The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R, R, Rand X are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

The invention relates to oxazolopyrimidine compounds of formula (I), where A, R, R, R, R, X and Y are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing. 

Heterocyclic carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring

Heterocyclic carboxylic acid derivatives comprising a 2,5-substituted oxazolopyrimidine ring as Edg-1 receptor agonists The present invention relates to oxazolopyrimidine compounds of the formula I, in which A, R, R, R, X and Y are defined as indicated in the claims. The compounds of the formula I modulate the activity of the Edg-1 receptor and in particular are agonists of this receptor, and are useful for the treatment of diseases such as atherosclerosis, heart failure or peripheral arterial occlusive disease, for example. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Heterocyclic carboxylic acid derivatives having a 2,5-substituted oxazolopyrimidine ring

The invention relates to oxazolopyrimidine compounds of formula (I), where A, R, Rand Rare defined as stated in the claims. The compounds of formula (I) are suitable, for example, for wound healing. 

2,5,7-substituted oxazolopyrimidine derivatives

The invention relates to oxazolopyrimidine compounds of formula (I), where A, R, R, R, Rand X are defined as stated in the claims. The compounds of formula I are suitable, for example, for wound healing. 

Carboxylic acid derivatives having a 2,5,7-substituted oxazolopyrimidine ring

The present invention relates to cycloalkyloxycarboxylic acid derivatives of the formula I in which A, R, R, R, R, Rand X are as defined in the claims. The compounds of the formula I are suitable, for example, for wound healing.

Cycloalkyloxycarboxylic acid derivatives

The invention therefore relates to compounds of the formula I in which X, Y, R, Rand Rhave the given meanings. The compounds of the formula I are suitable, for example, for wound healing.

Growing community of inventors

Frankfurt am Main, Germany

Thomas Huebschle