Thomas Helledays Stiftelse for Medicinsk Forskning

Kancera Ab

Thomas Helleday

Tobias Koolmeister

Martin Scobie

Sylvain Jacques

Evert Homan

Olov Wallner

Carl Martin Henriksson

Karl Sven Axel Vallin

Martin Haraldsson

Martin Henriksson

Matthieu Frederik Desroses

Lars Sandberg

Sanjay Borhade

Christoffer Bengtsson

Cynthia Paulin

Roland Julius Yu Fiskesund

Pål Stenmark

Karl Vallin

Torkild Visnes

Marie-Caroline Jacques-Cordonnier

Rune Ringom

Jessica Martinsson

Mattias Joensson

Katarina Faernegardh

Nina Gustafsson Sheppard

Petra Groth

Armando Cázares-körner

A compound of formula I or a pharmaceutically acceptable salt thereof. The compound is useful in therapy, e.g. for the treatment of cancers, inflammation, autoimmune diseases and graft-versus host diseases (e.g. in transplantation patients). A pharmaceutical composition comprising the compound or its salt and a method for preparing the compound.

2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy

There is provided herein a compound of formula I or a pharmaceutically acceptable salt thereof, wherein R, R, X, X, Yto Y, Zto Z, and n have meanings provided in the description.

Substituted benzodiazoles and use thereof in therapy

There is provided herein a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R, R, X, X, Yto Y, Zto Zand n have meanings provided in the description.

A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is useful in therapy, e.g. for the treatment of cancers, inflammation, autoimmune diseases and graft-versus host diseases (e.g. in transplantation patients). A pharmaceutical composition comprising the compound or its salt and a method for preparing the compound. 

A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions. 

MTH1 inhibitors for treatment of inflammatory and autoimmune conditions

A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer. 

MTH1 inhibitors for treatment of cancer

A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Pyrimidine-2,4-diamine derivatives for treatment of cancer

A compound of formula (I) useful for the treatment of cancer, inflammation and inflammatory disorders, and a pharmaceutical composition containing the compound.

Bisarylsulfonamides useful in the treatment of inflammation and cancer

A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1. 

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Thomas Helleday