Other

Friedrich-Alexander-Universitat Erlangen-Nürnberg

Asta Pharma Aktiengesellschaft

Max-Delbruck-Centrum Fur Molekulare Medizin

Thomas Harrer

Bernhard W Fleckenstein

Gerd Wallukat

Andreas Baur

Joachim Kalden

Angela Hückelhoven

The present invention relates to specific T-cell receptor a-chains, T-cell receptor &#x3b2;-chains and T-cell receptors comprising said T-cell receptor a-chain and/or &#x3b2;-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or &#x3b2;-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or &#x3b2;-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.

Influenza-specific T-cell receptor and its uses in the detection, prevention and/or treatment of influenza

The invention relates to nucleic acid molecules encoding peptides which are directed against autoantibodies associated with cold allergy, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said nucleic acid molecules and peptides for the treatment of circulatory disorders associated with exposure to cold or intolerance to cold, especially cold allergies.

Peptides against autoantibodies causing intolerance to cold and use thereof

Pharmaceutical compositions containing at least one compound of Formula I, ##STR1## where X is a hydrogen atom or both X's represent a direct link between the two sulphur atoms; Y is hydrogen or C.sub.1 -C.sub.6 alkyl and n represents a number from 1 to 10, or their pharmaceutically acceptable salts including .alpha.-lipoic acid and dihydrolipoic acid. The pharmaceutical compositions are useful for the treatment of diseases caused by retroviruses.

Pharmaceutical compositions containing as active substance

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Erlangen, Germany

Thomas Harrer