Norchip A/s

Thomas Hansen-Hagge

Frank Karlsen

Klaus Stefan Drese

Rainer Gransee

Tobias Baier

Lars A Solli

Anja Gulliksen

Liv Furuberg

The present invention provides an integrated lab-on-a-chip device for carrying out a nucleic acid extraction process on a fluid sample containing cells and/or particles, the device comprising: (a) a sample inlet () for loading of a fluid sample, (b) a lysis unit () for lysis of cells and/or particles present in the fluid sample, (c) a reservoir of lysis fluid () for the lysis unit, (d) a nucleic acid extraction unit () downstream of the lysis unit, and (e) reservoirs of first washing buffer and eluant fluid () for the nucleic acid extraction unit, wherein the device further comprises (f) a mixing unit () downstream of the nucleic acid extraction unit, and (g) a source of mixing fluid () for the mixing unit. The reservoirs of lysis fluid, first washing buffer and eluant fluid may be provided parallel to one anther so that they may be actuated by a single pump.

Device for carrying out cell lysis and nucleic acid extraction

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Mainz, Germany

Thomas Hansen-Hagge