Technische Universitát Dresden

Technische Universitä{umlaut Over ( )}T Dresden

Leibniz-institut Fur Polymerforschung Dresden E.v.

Thomas Hanke

Hartmut Worch

Sascha Heinemann

Dieter Scharnweber

Wolfgang Pompe

Sophie Roessler

Christiane Heinemann

Petra Uhlmann

René Beutner

Bernd Schwenzer

Jan Michael

Ulla KÖNIG

Yuichiro Ueda

Hermann Ehrlich

The invention relates to novel composite materials based on a collagen matrix mineralized with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralized with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analog, a collagen derivative or a mixture of said collagens.

Composite material consisting of a collagen matrix mineralised with silicate and calcium phosphate phases, method for the production and use thereof

The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.

Growth-inhibited hydroxyapatite, process for its preparation and use

A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5'-terminal or 3&#x2032;-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.

Metallic object with a nucleic acid coating and derivatives thereof and method for producing said object

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Berlin, Germany

Thomas Hanke