Neumodx Molecular, Inc.

Translume, Inc

Accumed Systems, Inc.

Thomas Haddock

Sundaresh N Brahmasandra

Jeffrey S Williams

Patrick Duffy

Ali Said

Mark Allen Dugan

Philippe Bado

William W O'Neill

A system for thermocycling biological samples within detection chambers comprising: a set of heater-sensor dies, each heater-sensor die comprising a heating surface configured to interface with a detection chamber and a second surface, inferior to the heating surface, including a first connection point; an electronics substrate, comprising a first substrate surface coupled to the second surface of each heater-sensor die, an aperture providing access through the electronics substrate to at least one heater-sensor die, and a second substrate surface inferior to the first substrate surface, wherein the electronics substrate comprises a set of substrate connection points at least at one of the first substrate surface, an aperture surface defined within the aperture, and the second substrate surface, and wherein the electronics substrate is configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of wire bonds, including a wire bond coupled between the first connection point of at least one of the set of heater-sensor dies and one of the set of substrate connection points.

Thermocycling system and manufacturing method

A system and method of manufacture for the system, comprising a set of heater-sensor dies, each heater-sensor die comprising an assembly including a first insulating layer, a heating region comprising an adhesion material layer coupled to the first insulating layer and a noble material layer, and a second insulating layer coupled to the heating region and to the first insulating layer through a pattern of voids in the heating region, wherein the pattern of voids in heating region defines a coarse pattern associated with a heating element of the heating region and a fine pattern, integrated into the coarse pattern and associated with a sensing element of the heating region; an electronics substrate configured to couple heating elements and sensing elements of the set of heater-sensor dies to a controller; and a set of elastic elements configured to bias each of the set of heater-sensor dies against a detection chamber.

Thermocycling system, composition, and microfabrication method

A fuel injector and a method for manufacturing a fuel injector are described. The fuel injector includes a glass substrate and a nozzle enclosed within the glass substrate. The nozzle includes at least one injection hole. The method of manufacturing a fuel injector includes defining a shape of at least one injection hole in a glass substrate to obtain an at least one outlined injection hole and etching the at least one outlined injection hole to obtain the at least one injection hole.

Fuel injector

A method continuously monitors variations in the size of particles present in a fluid on a real time basis. The method includes passing one or more optical signal through the fluid such as engine oil. The variation (attenuation or enhancement) in the intensity of the optical signal is continuously measured with respect to time. In an embodiment, the method enables monitoring of the amount, size and onset of particle agglomeration using single or multiple wavelengths as interrogating optical signal(s). An exemplary embodiment is provided for monitoring of the amount, size and onset of soot particle agglomeration in engine oil using single or multiple wavelengths as interrogating optical signal(s).

Particle size variation monitoring in a fluid

A method and apparatus for manufacturing a fuel injector comprising a glass substrate and a nozzle enclosed within the glass substrate, wherein the nozzle comprises at least one injection hole is provided. The method of manufacturing the fuel injector comprises defining () a shape of at least one injection hole in a glass substrate to obtain an at least one outlined injection hole and etching () the at least one outlined injection hole to obtain the at least one injection hole.

Method of manufacturing a glass fuel injector

The present invention relates to a method, system and apparatus for continuously monitoring variations in the size of particles present in a fluid on a real time basis. The method comprises of passing one or more optical signal through the fluid such as engine oil. The variation (attenuation or enhancement) in the intensity of the optical signal is continuously measured with respect to time. In an embodiment, the method, system and apparatus of the present invention enable monitoring of the amount, size and onset of particle agglomeration using single or multiple wavelengths as interrogating optical signal(s). An exemplary embodiment is provided for monitoring of the amount, size and onset of soot particle agglomeration in engine oil using single or multiple wavelengths as interrogating optical signal(s).

Method, system and apparatus for monitoring variations in the size of particles present in a fluid

A thermal sensing catheter finds particular utility in detecting and isolating unstable arterial plaque. Miniaturized temperature sensors, preferably in the form of microthermistors, are embedded into expandable presentation elements disposed at the distal end of a catheter. The sensors may then be deployed to measure the surface temperature of the inner wall of coronary arteries or other vessels at multiple sites to identify sites of elevated temperature indicative of unstable plaque. The presentation elements may assume a &ldquo;hand&rdquo; type design or an alternate basket-type structure. A plurality of thermal sensors are embedded into the sides of polymeric or metallic sensing elements which expand out from the centerline of a catheter toward the inner vessel walls.

Growing community of inventors

Ann Arbor, MI, United States of America

Thomas Haddock