Nicoventures Trading Limited

Rai Strategic Holdings, Inc.

Thomas H Poole

Anthony Richard Gerardi

Christopher Keller

Ronald Keith Hutchens

Darrell Eugene Holton, Jr

Frank Kelley St Charles

Dwayne William Beeson

Steven Lee Alderman

Chris J Grimes

Andries Don Sebastian

Michael Andrew Zawadzki

Kristen Ann Spielbauer

Andinet Amare Gessesse

Nicolas Von Cosmos

Philip Richard Hunt

Timothy Brian Nestor

Gary Maurice Dull

Wesley Steven Jones

David Neil McClanahan

Serban C Moldoveanu

John E Bunch

Ross Jay Oden

Matthew Evan Lampe

Savannah Johnson

Travis O'Neal

Richard Svensson

Allen Riggins

Brian Michael Keyser

Provided herein are pouched products including a chromogenic material or an electronic component, wherein the chromogenic material and the electronic component are responsive to a stimulus. The stimulus may be a change in pH, a change in temperature, or exposure to moisture. Such pouched products can be employed to detect various changes associated with the pouched product.

Stimulus-responsive pouch

The disclosure provides for an oral composition, the oral composition including at least one active agent, at least one filler component, and water in an amount sufficient such that the oral composition has a total moisture content of about 15% to about 30% by weight or greater based on the total weight of the oral composition.

Moist oral compositions

The disclosure provides for oral compositions and products that can have a relatively low water content and/or a relatively low water activity. Such compositions and products can comprise at least one active ingredient, a filler/carrier component, and water in an amount of less than 10% by weight, based on the total weight of the composition. Further, the compositions and products can have a water activity of about 0.85 or less.

Oral compositions with reduced water activity

The disclosure provides products configured for oral use, the products including one or more active ingredients and a beet material, at least a portion of the one or more active ingredients being bound to the beet material. In some embodiments, oral products as described herein may include a beet material, a filler material, and one or more active ingredients, at least a portion of the one or more active ingredients being bound to the beet material and the filler material. Active ingredients included in the product may be configured for release according to different release rates, which rates may depend at least in part on the material to which the active ingredient is bound.

Oral composition with beet material

Meltable compositions configured for oral use, the compositions including at least one cannabinoid or cannabimimetic, are provided. The compositions include one or more fillers, typically a sugar alcohol, and a lipid. A method of forming such compositions is also provided.

Oral cannabinoid product with lipid component

The disclosure provides products configured for oral use, the products including a mixture of a particulate filler component, a cellulose derivative, water, and one or more flavoring agents. The products exhibit greater stability over time with respect to flavor component concentration than comparative products which do not contain a cellulose derivative.

Oral product with cellulosic flavor stabilizer

The disclosure provides a nanoemulsion including an oil phase containing at least one cannabinoid and a water phase; wherein at least one of the oil phase and the water phase includes one or more emulsifying agents; and wherein the zeta potential of the nanoemulsion is less than about −10 mV. Further provided are processes for preparing such nanoemulsions.

Process of making nanoemulsion

A method for preparing an aerosol precursor composition is provided, which includes the steps of providing a first aqueous solution comprising one or more organic acids in water; subjecting the first aqueous solution to hydrolysis to give a hydrolyzed aqueous solution with a higher organic acid monomer content on a dry weight basis than in the first aqueous solution; and combining the hydrolyzed aqueous solution with one or more aerosol formers to give an aerosol precursor composition. Typically, the aerosol precursor composition further contains nicotine. The disclosed method can lead to enhanced control over the composition and characteristics of the produced aerosol precursor composition.

Method for hydrolysis of lactic acid for aerosol delivery device

The disclosure provides for oral compositions that exhibit desired properties associated with moist products while incorporating a relatively low water content. Such compositions may include at least one releasable material, at least one filler/carrier component, and at least one water substitute, such as a polyol. The water substituted may be present in an amount of about 25% by weight or greater based on the total weight of the oral composition, and the compositions and products formed therewith can exhibit a relatively low water activity, such as in the range of about 0.85 or less. The present disclosure further provides methods of forming an oral composition with a mouthfeel corresponding to a moist product while having a relatively low water activity.

Oral compositions with reduced water content

The disclosure provides products configured for oral use, the products including a mixture of a particulate filler, water, one or more organic acids, and one or more flavoring agents, the product having a pH value of less than about 7.0. The products exhibit greater stability over time with respect to whiteness and/or flavor component concentration than products which do not contain one or more organic acids.

Pouched products with enhanced flavor stability

A composition configured for oral use is provided, the composition including a filler in an amount of at least 20% by weight, based on the total weight of the composition, and at least one active ingredient including one or more botanical materials, stimulants, amino acids, vitamins, antioxidants, cannabinoids, pharmaceutical agents, or a combination thereof. The composition further includes a salt and at least one sweetener. The composition has a moisture content of at least about 40% by weight, based on the total weight of the composition.

Oral products

The disclosure provides a composition configured for oral use, the composition including a filler in an amount of at least 20% by weight, based on the total weight of the composition, and at least one active ingredient including one or more botanical materials, stimulants, amino acids, vitamins, antioxidants, cannabinoids, pharmaceutical agents, or a combination thereof. The composition further includes a salt and at least one sweetener. The composition has a moisture content of at least about 40% by weight, based on the total weight of the composition.

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Winston-Salem, NC, United States of America

Thomas H Poole