Eli Lilly and Company

Thomas H Ferguson

David Edward Tupper

Charles A Bunnell

Barry A Hendriksen

Manuel V Sanchez-Felix

Douglas J Allen

Sharon L Shinkle

Norman D Brooks

Daniel S Skinner, Jr

Kurt D Dekemper

Linda C Murray

Stuart J Garvin

Snehlata S Mascarenhas

Jose De Leon

Roger G Harrison

David L Moore

The invention provides a pharmaceutically acceptable oleaginous or cholesterol microsphere formulation of olanzapine or olanzapine pamoate or solvates thereof. The invention further provides novel olanzapine pamoate salts or solvates thereof.

2-methyl-thieno-benzodiazepine formulation

The invention provides a pharmaceutically acceptable oleaginous or cholesterol microsphere formulation or olanzapine or olanzapine pamoate or solvates thereof. The invention further provides novel olanzapine pamoate salts or solvates thereof.

A dairy cow injected with a sustained release formulation comprising bovine somatotropin, a wax, and an oil produces more milk for 28 days.

Injectable sustained release formulation

Uniform adherent coatings of antimicrobial agents are applied to the surface of implants by applying a film of silicone oil to the surface of the implant and then contacting the film-bearing surface with antimicrobial agents in a film-adherent powder form. A durable antimicrobial coating is formed. The coated implants can be packaged using mechanized implant handling equipment without significant loss of the antimicrobial coating.

Method of making antimicrobial coated implants

Uniform adherent coatings of antimicrobial agents are applied to the surface of implants by applying a film of silicone oil to the surface of the implant and contacting the film-bearing surface with antimicrobial agents in a film-adherent form. A durable antimicrobial coating is formed. The coated implants can be packaged using mechanized implant handling equipment without significant loss of the antimicrobial coating. In a preferred embodiment a controlled-release implant for administering an anabolic agent is coated with a durable nonvulcanizing silicone fluid plus oxytetracycline hydrochloride coating which does not interfere with diffusion of the anabolic agent from the implant.

Antimicrobial coated implants

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Greenfield, IN, United States of America

Thomas H Ferguson