Transmedics, Inc.

Thomas H Bishop

Scott W Newell

Waleed H Hassanein

Tamer I Khayal

Richard Bringham

Stanley Kyi

Robert Fishman

John Sullivan

Robert Havener

Mark Anderson

Ihab Abdel Fattah

Anas Abdelazim

Doug Harriott

Matthew De Remer

Paul Murray

Michael Van Driel

Ronald Taylor

Ron Taylor

Dmitri Menn

Giovanni Cecere

Burt Ochs

Hossam Algamil

Robert Havner

Larry Goff

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Systems and methods for ex vivo lung care

The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.

Method of timing pulsatile flow of normothermic perfusate to the heart

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Wenham, MA, United States of America

Thomas H Bishop