The Hospital for Sick Children

Hsc Research and Development Limited Partnership

Hsc Research and Development Limited

Thomas Grunberger

Chaim M Roifman

Olga Rounova

Nigel Sharfe

Peter M Demin

Andrew Freywald

Demin Peter

Octavian Laurand Cimpean

Eyal Gruebaum

Peter Demin

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.

Compounds for modulating cell proliferation

The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Formula (I), (II), wherein R, Rand Rare each independently selected from H, OH, Calkyl, Calkoxy, NH, NH&#x2014;Calkyl, N(Calkyl), SH, S&#x2014;Calkyl, NO, CF, OCFand halo; Ris unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from Calkyl, Calkoxy and halo; X is selected from (CHCHO)and (CH), and n=1-4. 

Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signaling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.

Methods of modulation of the immune system

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders  such as cancer are disclosed. The compounds are of Formula (I).

Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I:

Growing community of inventors

Toronto, Canada

Thomas Grunberger