Dendreon Corporation

Allozyne, Inc.

Thomas Graddis

Reiner Laus

Damir Vidovic

Kenneth H Grabstein

Natalie Winblade Nairn

David Duncan

Aijun Wang

Sateesh Kumar Natarajan

Michael Diegel

Feng Chen

Deepshikha Datta

Stephen McCraith

Damis Vidovic

Provided are alternative reading frame (ARF) polypeptides as well as antigen presenting cell (APC) and dendritic cell (DC) based compositions that comprise ARF polypeptides. ARF polypeptides and ARF polypeptide-based compositions are useful in the treatment of cancer and infectious disease.

Compositions employing alternative reading frame polypeptides for the treatment of cancer and infectious disease

The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the invention also relate to kits for identifying, modifying and producing modified target molecules described herein.

Modified human interferon-beta polypeptides

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

Compositions and methods for the treatment of disease associated with TRP-P8 expression

Compositions and methods for the treatment of disease associated with Trp-p8 expression

Methods of modifying polypeptides comprising non-natural amino acids

Disclosed are immunostimulatory fusion proteins and methods for generating protective DC-induced, T cell-mediated immune responses in vitro and in vivo. The immunostimulatory fusion proteins comprise a polypeptide antigen component and an immunostimulatory component derived from the intracellular domain of the HER-2 protein. Also disclosed are immunostimulatory compositions comprising dendritic cells pulsed with such an immunostimulatory fusion protein and methods for immunotherapy using the compositions.

Compositions and methods for dendritic cell-based immunotherapy

Provided are alternative reading frame (ARF) polypeptides as well as antigen presenting cell (APC) and dendritic cell (DC) based compositions and methods that employ alternative reading frame polypeptides. ARF polypeptides and ARF polypeptide-based compositions and methods are useful in the treatment of cancer and infectious disease.

Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious disease

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Seattle, WA, United States of America

Thomas Graddis