Syngenta Crop Protection, Inc.

Novartis Crop Protection, Inc.

Thomas Gobel

Thomas Pitterna

Henry Szczepanski

Anthony Cornelius O'Sullivan

Thomas Rapold

Marcel Senn

Ottmar Franz Huter

Peter Maienfisch

Gottfried Seifert

Peter Mainenfisch

A process is provided for preparing compounds having the general formula I wherein R is a range of organic groups and X is a leaving group. The process comprises reacting a compound of formula II with a water-removing reagent. When X is halogen or a sulfonate, the compound of formula I may be prepared by reacting a compound of the formula III with a halogenating agent or a sulfonylating agent. Alternatively, when X is halogen, the compound of formula I can be prepared by reacting a compound of the formula IV where R2 and R2 are defined organic groups, with a compound of the formula halogen-C(&#x2014;O)&#x2014;O&#x2014;C1-C8alkyl, halogen-C(&#x2014;O)&#x2014;O-aryl or halogen-C(&#x2014;O)&#x2014;O-benzyl.

Preparation of thiazoles

A process for the preparation of a compound of formula I wherein R is a range of organic groups and X is a leaving group which process comprises a) reacting a compound of the formula II where R is defined for formula (I) with a water-removing reagent; or b) for the preparation of a compound of formula (I) wherein K is halogen or a sulfonate, reacting a compound of the formula III where R is defined for formula (I) with a halogenating agent or a sulfonylating agent; or c) for the preparation of a compound of formula (I) wherein X is halogen, reacting a compound of the formula IV where R is as defined for formula (I) and R2 and R3 are defined organic groups with a compound of the formula halogen-C(&#x2014;O)&#x2014;O&#x2014;C1-C8alkyl, halogen-C(&#x2014;O)&#x2014;O-aryl or halogen-C(&#x2014;O)&#x2014;O-benzyl.

The present invention is directed to a process for preparing a compound having the formula: wherein R is a range of organic groups and X is a leaving group. The process may include reacting a compound of the formula with a water-removing reagent. Also, when X is a halogen, the process may include reacting a compound of the formula with a halogenating agent or a sulfonylating agent. Alternatively, when X is a halogen, the process may be carried out by reacting a compound of the formula IV where Rand Rare defined organic groups with a compound of the formula halogen-C(&#x2014;O)&#x2014;O&#x2014;C1 -C8alkyl, halogen-C(&#x2014;O)&#x2014;O-aryl or halogen-C(&#x2014;O)&#x2014;O-benzyl.

Process for the preparation of thiazole derivatives

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Lorrach, Germany

Thomas Gobel