Bayer Aktiengesellschaft

Troponwerke Gmbh & Co Kg

Troponwerke Gmbh & Co.

Thomas Glaser

Hans-Georg Heine

Bodo Junge

Henning Sommermeyer

Rudolf Schohe-Loop

Jorg Traber

Klaus Urbahns

Reilinde Wittka

Jean-Marie-Viktor De Vry

Wolfgang Dompert

Peter-Rudolf Seidel

Rudolf Schohe

George S Allen

Teunis Schuurman

Jean M De Vry

Siegfried Goldmann

Harald Horstmann

Hartmund Wollweber

Ulrich Benz

Jean Marie Viktor De Vry

Bernd Richter

Jean-Marie Viktor De Vry

Egbert Wehinger

Otto Behner

Jean-Marie V De Vry

Dieter Arlt

Joachim Schuhmacher

Siegfried Raddatz

Frank Mauler

Arno Friedl

Reinhard Jork

Wolfgang Kanhai

Ervin Horvath

J Org Traber

Allen, George

Teunis Schuurmann

Teunis Thurman

The invention relates to the use of 5-substituted pyridine- and hexahydroquinoline-3-carboxylic acid derivatives, some of which are known, for the production of medicaments, in particular for the treatment of cerebral disorders.

Use of 5-substituted pyridine and hexahydroquinoline-3 carboxylic acid derivatives for treating diseases of the central nervous system

The present invention relates to the new use of 1,2-bridged 1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 and a have the meaning indicated in the description, processes for their preparation and their use as medicaments, as selective potassium channel modulators, in particular for the treatment of the central nervous system.

Use of 1,2-Bridged 1,4-dihydropyridines as medicaments

The present invention relates to new 2,3-bridged 1,4-dihydropyridines of the general formula (I), ##STR1## in which R, R.sup.1, R.sup.2, D and E have the meaning given in the description, processes for their preparation and their use as medicaments, preferably for treatment of the central nervous system.

2,3-bridged 1,4-dihydropyridines, and their use as medicaments

Triazaspirodecanone-methylchromans are prepared by reacting methylchromans, which are substituted on the methyl group by appropriate leaving groups, with triazaspirodecanones. The substances can be employed for the production of medicaments, in particular for medicaments for the control of disorders of the central nervous system.

Triazaspirodecanone-methylchromans

Use of 1,2-bridged 1,4-dihydropyridines as medicaments

Diseases characterized by disturbances of the serotoninergic system, psychoses and depression are treated by administration of an aminomethyl-chroman of the formula ##STR1##

2-aminomethyl-chromans effective in the treatment of psychoses and

The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.

Use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters as medicaments

The present invention relates to the new use of 1-alkyl-3,5-diacyl-1,4-dihydropyridines which are known in some cases, of the general formula (I) ##STR1## in which R.sup.1 to R.sup.4 have the meaning indicated in the description, processes for their preparation and their use as medicaments, as selective potassium channel modulators, in particular for the treatment of the central nervous system.

5-acyl-1,4-dihydropyridines

The benzisothiazolyl-substituted aminomethylchromans are prepared either by substituting the corresponding unsubstituted aminomethylchromans on the amine nitrogen or reacting the corresponding benzisothiazolylalkylamines with appropriate activated methylchromans or reacting the amine nitrogen of aminomethylchroman first with an appropriately substituted alkine and then hydrogenating. The benzisothiazolyl-substituted aminomethylchromans can be used as active compounds in medicaments, in particular in medicaments for the treatment of disorders of the central nervous system.

Benzisothiazolyl-substituted aminomethylchromans

Use of substituted 6-amino-4H-pyrans

Use of N-substituted phenothiazines

The substituted 4H-pyrans are prepared by reacting either aldehydes or ylidene compounds with suitably substituted .beta.-diketones. The substituted 4H-pyrans according to the invention are suitable as active compounds in medicaments, in particular for the treatment of disorders of the central nervous system.

Substituted 4H-pyrans

Dioxo-thiopyrano-pyridine-carboxylic acid derivatives and their use as

Azaheterocyclylmethyl-chromans of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R.sup.6 represents hydrogen, hydroxyl, halogen or phenyl; and

Azaheterocyclymethyl-chromans

A method of treating psychosis by administering to a patient an azaheterocyclylmethyl-chroman of the formula: ##STR1## in which E represents an azaheterocyclyl group selected from the group consisting of: ##STR2## wherein R.sup.6 represents hydrogen, hydroxyl, halogen or phenyl; and represents an integer 0-8; and the other substituents are as defined herein; or an optically isomeric form thereof or a salt thereof.

Method of treating psychosis using azaheterocyclylmethyl

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Overath, Germany

Thomas Glaser