Hemosonics LLC

Biomerieux, Inc.

Thomas Givens

William F Walker

Andrew Homyk

Francesco Viola

David Bryant

F Scott Corey

Timothy Higgins

Paul Joseph Braun

Franklin F Regan

Franklin Francis Regan, Iv

Cynthia Ann Lloyd

Timothy J Fischer

Lisa Beck

Franklin F Iv Regan

A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.

Disposable system for analysis of hemostatic function

Transparent hemostasis measurement cartridge

Hemostasis measurement cartridge

A method is disclosed for predicting the presence of an abnormal level of one or more proteins in the clotting cascade from at least one time-dependent measurement profile. At least one time-dependent measurement on an unknown sample is performed and a respective property of said sample is measured over time so as to derive a time-dependent measurement profile. A set of a plurality of predictor variables are defined which sufficiently define the data of the time-dependent measurement profile. A model is then derived that represents the relationship between the abnormality and the set of predictor variables. Subsequently, the model is utilized to predict which protein or proteins in the clotting cascade are at an abnormal level, with the prediction being a more informative prediction than clot time alone.

Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade

A method for presenting relationships between data from a thrombosis-hemostasis assay on an unknown sample and data from a purality of assays on known samples, which can be in the form of a topological feature map wherein spatial locations within the map correspond to intrinsic features of the known samples. The position of the unknown sample is superimposed on the positions of the known samples. An alternative presentation is showing the distance of each of a purality of predictor variables from an unknown sample to the mean values of a known population.

Method for presenting thrombosis and hemostasis assay data

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Rougemont, NC, United States of America

Thomas Givens