National University of Ireland, Galway

Enterprise Ireland

National University of Ireland

Thomas Gerard Barry

Terence James Smith

Majella Maher

Kate Mary Reddington

Nina Tuite

Justin Joseph O'Grady

Terry James Smith

Louise O'Connor

Elizabeth Minogue

Sinead Lahiff

Marcin Jankiewicz

Terry James Smth

Jankiewicz Marcin

Justin O'GRADY

This invention relates to the detection of, more specifically, more specificallyserogroup 1, in a sample. Methods of detection, and assays and kits useful for detection, are also disclosed. The invention provides a method for identifying the presence, absence, or quantity ofserogroup 1 in a sample, the method comprising the steps of detecting the presence, absence, or quantity of at least part of the nucleic acid sequence of the lpg0768 gene or an expression product thereof, and correlating the presence, absence, or quantity of the at least part of the nucleic acid sequence of the lpg0768 gene or an expression product thereof, to the presence, absence, or quantity ofserogroup 1 in the sample.

Method for the detection of legionella

A method for determining the presence or absence of a member of a group of bacterial organisms in a sample, wherein the method comprises determining whether a target region of the smpB gene is present in said sample is provided. Primers, probes and kits for use in these methods also form part of the invention, as does the use of an smpB gene target region to detect the presence or absence of a member of a group of bacterial organisms in a sample, in a range of clinical and non-clinical applications.

Diagnostic method for bacterial organisms using the smpB gene

The present invention relates to a multiplex in vitro nucleic acid amplification method for identifying a species of thecomplex present in a sample. The method includes detecting the presence or absence of a plurality of nucleic acid molecule targets in the sample in one reaction, wherein at least one of the nucleic acid molecule targets is present in the genome of one or more, but not all, of the species of thecomplex. The invention also includes kits containing primers or probes for conducting this method, nucleic acids useful for performing this method and diagnostic techniques using these nucleic acids.

Diagnostic method

The current invention relates to a diagnostic kit for a yeast or fungal species comprising at least one oligonucleotide probe capable of binding to at least a portion of the eIF2y gene or its corresponding mRNA.

eIF2&#x3b3; gene as a diagnostic target for the identification of fungal and yeast species

The invention relates to the SWI5 gene, the corresponding RNA, specific probes, primers and oligonucleotides related thereto and their use in diagnostic assays to detect and/or discriminate between fungal and yeast species.

SWI5 gene as a diagnostic target for the identification of fungal and yeast species

The present invention use of to a portion of the RPS7 gene or its corresponding mRNA in a diagnostic assay for fungal and yeast species and sequences for use in such assays and methods.

Nucleic acids probes for detection of yeast and fungal

The current invention relates to a diagnostic kit for a bacterial species and/or fungal and/or yeast species comprising at least one oligonucleotide probe capable of binding to at least a portion of the LepA and/or Guf1 genes or its corresponding mRNA.

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Use of the ssrA gene or tmRNA, an RNA transcript of the ssrA gene, or fragments thereof as target regions in a nucleic acid probe assay for the detection and identification of prokaryotic and/or eukaryotic organisms is described. Nucleotide sequence alignment of tmRNA sequences from various organisms can be used to identify regions of homology and non-homology within the sequences which in turn can be used to design both genus specific and species specific oligonucleotide probes. These newly identified regions of homology and non-homology provide the basis of identifying and detecting organisms at the molecular level. Oligonucleotide probes identified in this way can be used to detect tmRNA in samples thereby giving an indication of the viability of non-viral organisms present in various sample types.

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Kinvara, Ireland

Thomas Gerard Barry