Ici Pharma

Imperial Chemical Industries Limited

Zeneca Limited

Zeneca Pharma S. A.

Thomas G Bird

Philip N Edwards

Patrick Ple

Graham C Crawley

Frederic H Jung

Michael S Large

John F Kingston

Alain M Bertrandie

David Waterson

Jean-Marc M Girodeau

Martin P Edwards

Frederick H Jung

Jean C Arnould

Jean-Jacques M Lohmann

The invention concerns ether derivatives of the formula I

Ether derivatives having 5-lipoxygenase inhibitory activity

The invention concerns a heterocyclene derivative of the formula I ##STR1## wherein Ar.sup.1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety;

Heterocyclene derivatives

The invention concerns oxime derivatives of the formula I ##STR1## wherein R.sup.4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and (1-4C)alkyl;

Oxime derivatives

The invention concerns a thiazole derivative of the formula I ##STR1## wherein Q is 2-oxo-1,2,3,4-tetrahydroquinolin-6-yl or 2-oxo-1,2-dihydroquinolin-6-yl which bears on the nitrogen atom at the 1-position a (1-4C)alkyl substituent;

Thiazole derivatives

Substituted-optionally hydrogenated isoquinoline compounds,

The invention concerns a diaryl ether cycloalkane of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl; X.sup.1 is oxy, thio, sulphinyl or sulphonyl;

Diaryl ether cycloalkanes

The invention concerns a diaryl ether heterocycle of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;

Diaryl ether hetrocycles

The invention concerns a diaryl ether cyclic ether of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;

Diaryl ether cyclic ethers

The invention concerns a bicyclic derivative of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl; R.sup.1 if (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and

Bicyclic derivatives

Cephalosporin compounds having a 3-position substituent of the formula (I) are described:

Cephalosporin compounds

The invention concerns a thiazole of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted aryl of up to 10 carbon atoms;

Growing community of inventors

Witry-les-Reims, France

Thomas G Bird