Warner-lambert Company

Other

Parke-davis Company

Thomas F Mich

John Michael Domagala

Townley P Culbertson

Jeffrey B Nichols

Joseph P Sanchez

Theodore H Haskell

Dietrich Schweiss

Marland P Hutt, Jr

Leonard Doub

Carl L Heifetz

Om Prakash Goel

Francis John Tinney

Ernest D Nicolaides

James Andrew Ramsden

Thomas Mulhern

Ashok K Trehan

Marvin Simon Hoekstra

Mark Joseph Burk

Marland Paul Hutt

John M Doma

This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.

Asymmetric synthesis of pregabalin

Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

Naphthyridine antibacterial agents

Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Antibacterial agents - II

Certain quinolone and naphthyridine antibiotics are useful for treating ocular infections by topical administration.

Ophthalmic use of naphthyridine antibiotics

4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial

Novel naphthyridine-, quinoline- and benzoxazine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Antibacterial agents

Novel quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Opthalmic use of quinolone antibiotics

1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids and their esters, which are useful as intermediates for the preparation of compounds which are useful as anti-bacterial agents.

1-cyclopropyl-6,7-dihalo-1,4-dihydro-4-oxo-1,8-naphthyridine

Novel difluoro-naphthyridine- and trifluoroquinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.

Trifluoro- quinoline -3- carboxylic acids and their use as

Novel 1-aryl or heteroaryl-6,8-difluoro-1,4-dihydro-7-(3-aminomethyl)pyrrolidinyl- or 7-spiroamino-4-oxo-3-quinolinecarboxylic acids and acid derivatives thereof as antibacterial agents are described as well as methods for their manufacture, formulation and use in treating bacterial infections caused by Gram-negative and Gram-positive bacteria.

7-substituted

Novel 1-amino-naphthyridine- and quinoline-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.

Growing community of inventors

Ann Arbor, MI, United States of America

Thomas F Mich