US Government as Represented by the Secretary of the Army

The United States of America as Represented by the Secretary of

The Government of the United States of America, as Represented by the

Thomas F McCutchan

John B Dame

Imogene Schneider

Richard Wistar, Jr

Jackie L Williams

An immunologically active substantially pure peptide capable of inducing in human an immune response which is cross reactive with and protective against infection by a malaria parasite, wherein the peptide contains at least 2 consecutive repeats of a sequence Asn-X-Y-Pro wherein X is Ala or Val and Y is Asn or Asp or a sequence of the formula Thr-Glu-Trp-Z-Pro-Cys-Ser-Val-Thr-Cys-Gly-Asn-Gly wherein Z is Ser or Thr or the formula Lys-Pro-S-T-S-Lys-Leu-Lys-Gln-Pro-U-V-Gly-W-Pro wherein S is Lys or Asn, T is His or Glu, U is Gly or Asn, V is As or Glu, and W is Asn or Gln is disclosed along with DNA sequences and various other genetic materials useful in producing these peptides through biological methods.

Immunologically active peptides capable of inducing immunization against

The present invention discloses isolated functionally intact whole genes and method of obtaining the same. The method includes treating genomic DNA with mung bean nuclease and formamide under controlled conditions. The invention also discloses cloning of said intact whole genes and a library of such cloned genes or any recombinations thereof. The invention is useful in deriving gene products as m-RNA, S-RNA, t-RNA, polypeptides and the like.

Intact gene and method of excising and cloning same

The present invention discloses a synthetic peptide capable of inducing antibodies protective against human malarial infection caused by Plasmodium vivax sporozoites and the cloning of a gene encoding said peptide. The amino acid and nucleotide sequences of the peptide and the gene, respectively, have been determined and described.

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Silver Spring, MD, United States of America

Thomas F McCutchan