Tissue Genesis Incorporated

Other

Thomas F Cannon

Paul Kosnik

Stuart K Williams

Christian Leon Haller

Charles P Luddy

Erik Vossman

Jennifer L Case

Gregory D Ariff

Craig A Mauch

Laura K Cohn

Peter D Quinn

Bernard A McCarthy

Jane E Cowan

Frances G Cannon

The present invention provides automated devices for use in supporting various cell therapies and tissue engineering methods. The present invention provides an automated cell separation apparatus capable of separating cells from a tissue sample for use in cell therapies and/or tissue engineering. The cell separation apparatus can be used in combination with complementary devices such as cell collection device and/or a sodding apparatus to support various therapies. The automated apparatus includes media and tissue dissociating chemical reservoirs, filters, a cell separator and a perfusion flow loop through a graft chamber which supports a graft substrate or other endovascular device. The present invention further provides methods for using the tissue grafts and cell samples prepared by the devices described herein in a multitude of therapies including revascularization, regeneration and reconstruction of tissues and organs, as well as treatment and prevention of diseases.

Cell separation apparatus and methods of use

The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in a standard laboratory or other incubator for provision of requisite gas and thermal environment. System cartridges are modular and can be operated independently or under a unified system controlling architecture, and provide for scale-up production of cell and cell products for research and clinical applications. Multiple replicates of the flowpath cartridges allow for individual, yet replicate cell culture growth and multiples of the experiment models that can be varied according to the experiment design, or modulated to desired cell development of cell culture end-points. The integral flowpath cartridge aseptic sampling system provides for dynamic analysis of metabolic products or representative cells from the culture.

Automated bioculture and bioculture experiments system

A drain guard is disclosed having a tubular body with a funnel-shaped portion at its upper end. The tubular body has an annular recess extending about the inside periphery thereof proximate the bottom end of the guard. The recess receives a sealing grommet therein for sealing the space between a tube on which the guard is positioned and the inner periphery of the tubular portion of the guard. Stop lugs are positioned about the inner periphery of the tubular portion of the guard at the junction of the funnel-shaped end portion thereof for limiting the upward movement of the tube on which the guard is positioned through the drain guard. A liquid permeable seat is positioned on the funnel-shaped end portion of the drain to permit the ingress of water or other liquids with respect to the drain guard. In an alternative embodiment of the invention, a rubber grommet is affixed to the inside periphery of the drain guard at the junction of the tubular and funnel shaped portions thereof with the grommet serving to limit the upward movement of the tube on which the guard is positioned and to seal the space between the guard and the tube to inhibit the passage of liquids therebetween.

Drain guard

Growing community of inventors

Glenwood, MD, United States of America

Thomas F Cannon