Roche Molecular Systems, Inc.

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Thomas Engel

Tobias Holenstein

Carsten Haack

Alessandro D'Amore

Adelrich Zuppiger

Roland Stoeckli

Thomas Sidler

Michael Meyberg

Tobias Greuter

A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

Pipetting device, modular pipetting unit, pipetting system and method for pipetting of fluid samples

A sample preparation dosing unit for liquid dosing is provided comprising an inlet port and an outlet port fluidically coupling the sample preparation dosing unit to a supply and target, respectively; a pump, fluidically arranged between the inlet port and the outlet port; an outlet flow restrictor with an outlet flow resistance, fluidically arranged between a pump outlet and outlet port; and a control arrangement with a branch, a control valve, and a control flow restrictor with a control flow resistance. The branch divides the flow at the pump outlet into an outlet flow through the outlet flow restrictor and into a control flow through the control flow restrictor. The control flow downstream of the control flow restrictor is fed, depending on the state of the control valve, either into the outlet port thereby merging with the outlet flow downstream of the outlet flow restrictor, or into a bypass conduit.

Sample preparation dosing unit

Growing community of inventors

Buonas, Switzerland

Thomas Engel