G.d. Searle & Company

Monsanto Company

Medibeacon Inc.

Pharmacia Corporation

Other

Mallinckrodt, Inc.

Pfizer Corporation

Thomas Edward Rogers

Joseph Gerace Rico

Mark Andrew Russell

Philippe R Bovy

Thomas Dale Penning

Balekudru Devadas

Peter Gerrard Ruminski

Jeffery A Zablocki

Michael John Clare

Ish K Khanna

Richard Bradley Dorshow

Foe S Tjoeng

James W Malecha

Barbara B Chen

Hwang-Fun Lu

Alan Frank Gasiecki

Bipinchandra N Desai

Srinivasan Raj Nagarajan

Masateru Miyano

Renee Huff

Raghavan Rajagopalan

Paul Waddell Collins

William L Neumann

Steven P Adams

Julie M Miyashiro

Stella S Yu

Nizal S Chandrakumar

Martin Paul Debreczeny

Helen Y Chen

Robert B Garland

Richard A Haack

Yi Yu

Lowell R Smith

Manuel M Baizer

Richard John Lindmark

Steven H Gray

David Adams

Chester Yuan

Xiaogang Hua

Glen J Gesicki

Lan Jiang

Philippe Roger Bovy

Jennifer VanCamp

John Nicholas Freskos

Daniel L Flynn

James P Coleman

Andrew Simon Bell

Mark Laurence Boys

Raymond C Grabiak

Shashidhar N Rao

Dafydd Rhys Owen

Richard C Hallcher

Dudley E McMackins

Lori A Schretzman

Gary B Gordon

Michael John Palmer

Joe T Collins

Sherrol L Baysdon

David Nathan Abraham Fox

David Graham Brown

Ian Roger Marsh

Foe Siong Tjoeng

Carol Ann Winslow

Andrew Ian Morrell

Jeffery Alan Zablocki

Robert E Jansson

John Adam Wendt

Albert Khilevich

Hwang-fun Lu

Heather Stenmark

Yaping Wang

G Allen Nickols

Norman Anthony Abood

Phillipe R Bovy

Jay Cunningham

William F Westlin

Peter Ruminiski

Mihir D Parikh

Yu Yi

Nagarajan R Srinivasan

Hwang Fun Lu

Kah Tiong Kuan

Lowell Richard Smith

The present invention provides methods for the purification of the compound of Formula (I) from the precipitated reaction product comprising the compound of Formula (I), impurities, and/or residual or entrained solvents.

Purification of substituted diaminopyrazine dicarboxylic acids

The present invention provides improved methods for preparing a compound comprising Formula (I).

Preparation of substituted diaminopyrazine dicarboxylic acids

Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.

Compositions and methods for assessing eye vasculature

A process for preparing pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is provided. A process for the preparation of 3,6-diaminopyrazine-2,5-dicarboxylic acid, or a salt thereof, from pyrimido[4,5-g]pteridine-2,4,7,9-tetraol, or a salt thereof, is further provided. A process for preparing a substituted pteridine compound, or a salt thereof, is further provided. A process for the preparation of a N-substituted 3,6-diaminopyrazine-2,5-dicarboxylic acid from a substituted pteridine compound, or a salt thereof, is further provided.

Anodic oxidation of 5-aminouracil

The stabilizing support device for cake fireworks is a device used to provide users with a supporting platform for fireworks, that prevents firework cakes from flipping over and causing unnecessary injuries. To accomplish this, the device includes a stable platform and a plurality of fastening means. Preferably, the device may hold a plurality of cake fireworks and may launch fireworks separately or all together. The device can further ignite the firework electronically through wireless communication. This can improve firework shows for everyday consumers can bring a backyard firework show to a professional firework display level. Furthermore, the device includes support stands that have the capabilities to shoot the fireworks in multiple angles and multiple heights. This can help families who have very little knowledge on how to put together a proper firework show. Additionally, the device can also be folded and fit into a small size carryon bag.

Stabilizing support device for cake fireworks

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a power supply, one or more sensors, and at least one tracer agent that fluoresces when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

Compositions and systems for renal function determination

The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula I to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.

Methods for renal function determination

The present invention provides phosphonate compounds and methods of preparing the phosphonate compounds so as to allow, for example, increased capability to modify nanoparticles for targeted drug delivery applications.

Remote assembly of targeted nanoparticles using H-phosphate ENE/-YNE hydrophosphonylation reactions

The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a nanoparticle to increase in vivo circulation times and targeted delivery performance.

Nanoparticle PEG modification with H-phosphonates

The present invention provides targeted delivery compositions and methods of using the compositions for treating and diagnosing a disease state in a subject.

MMP-targeted therapeutic and/or diagnostic nanocarriers

This invention relates to compounds of formula (I). 

Pyrazolo[4,3-D]pyrimidines

The present invention relates to a class of compounds represented by the Formula Ior a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &#x3b1;&#x3b2;and/or &#x3b1;&#x3b2;integrin.

Cycloalkyl alkanoic acids as integrin receptor antagonists

Growing community of inventors

Ballwin, MO, United States of America

Thomas Edward Rogers