Leica Microsystems Inc.

Reichert, Inc.

Thomas E Ryan

Christopher T Cotton

Jeffrey M Sabin

Michael J Byrne

Keshav D Sharma

Robert C Atkinson

Kyle R Bleyle

David J Cash

Timothy Levindofske

George S Baggs

An apparatus comprises a spectrophotometer system configured to measure light absorbance by a tear sample, a refractometer system configured to measure refractive index of the tear sample, and an evaluation unit programmed to calculate an osmolarity of the tear sample based on the measured absorbance and refractive index and stored calibration curves. The spectrophotometer and refractometer systems may share a common prism contacted by the tear sample during measurement. The evaluation unit may be programmed to carry out steps of a method for determining osmolarity of the tear sample in accordance with the invention. The osmolarity of the tear sample may be used as an indicator in diagnosing dry eye.

Apparatus and method for determination of tear osmolarity

An optical configuration for differential refractive index measurements of a test sample relative to a reference sample comprises an optical path along which an illumination beam travels to simultaneously illuminate a pair of optical interfaces on opposite sides of a meridional plane corresponding to the test sample and reference sample, respectively. Partial beams leaving the optical interfaces are optically diverged to illuminate different segments of a linear scanned array aligned in the meridional plane. The difference in location of a pair of shadowlines or a pair of resonance minimums formed by the partial beams on the array provides an indication of the refractive index difference.

Optical configuration and method for differential refractive index measurements

A refractometric apparatus and method for monitoring the percentage of water in hydraulic and non-hydraulic fluids employ a temperature sensitive device allowing a user to obtain accurate and correct readings of various measured properties. In particular, the temperature sensitive member comprises a prism-wedge-mirror combination in conjunction with a bimetallic strip. The combination ensures the proper angular displacement of a light beam inside the refractometric apparatus and, therefore, the correct reading of a parameter to be measured.

Refractometer for monitoring water content in fluids

A sensor apparatus and associated method for sensing and monitoring specific binding of analyte to an immobilized binding layer are disclosed. The apparatus preferably comprises an automatic critical angle refractometer having a linear scanned array and an optical system for illuminating a portion of the array, which illumination depends upon the refractive index of the binding layer deposited on an optically transparent element. The apparatus further includes a flow cell for bringing the analyte in contact with the binding layer. The apparatus also includes a computer for receiving and processing refractive index data from the critical angle refractometer during the reaction between the analyte and the layer, which computer may be peripherally connected to the refractometer or enclosed within the refractometer housing. A preferred sensing method of the present invention generally comprises providing a critical angle refractometer generating light impinging upon the immobilized binding layer, contacting the binding layer with a contacting phase, measuring the critical angle of total reflection, which measurements are indicative of the presence or absence of interactions between the analyte and the binding layer.

Refractomer and method for qualitative and quantitative measurements

A transmitted light refractometer comprises an optical system having a movable mirror for redirecting light transmitted through a light-refracting sample to a beam splitter for dividing the light between first and second detection paths. The first detection path leads to an eyepiece whereby an operator may view an illumination boundary shadowline brought into the field of view of the eyepiece by adjusting the position of the movable mirror. The second detection path leads to a light-sensitive detector, preferably a linear scanned array, for generating signal information indicative of the location of the shadowline on the detector. An optical position sensor associated with the movable mirror includes a position detector providing signal information indicative of the position of the movable mirror. During a reading, the shadowline is brought into the field of view of the eyepiece, and the shadowline signal information and the mirror position signal information are processed to calculate index of refraction of the sample.

Transmitted light refractometer

A refractometric apparatus and method for monitoring the percentage of water in hydraulic fluids employ a temperature sensitive device allowing a user to obtain accurate and correct readings of various measured properties. In particular, the temperature sensitive member comprises a prism-wedge-mirror combination in conjunction with a bimetallic strip. The combination ensures the proper angular displacement of a light beam inside the refractometric apparatus and, therefore, the correct reading of a parameter to be measured.

Brake check handheld refractometer

A refractometric apparatus and method for monitoring the percentage of water in hydraulic fluids employ a temperature sensitive device allowing a user to obtain accurate and correct readings of various measured properties on the reticle of the apparatus. In particular, the temperature sensitive member comprises a prism-wedge-mirror combination in conjunction with a bimetallic strip. The combination ensures the proper angular displacement of a light beam inside the refractometric apparatus and, therefore, the correct readings on the reticle.

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Batavia, NY, United States of America

Thomas E Ryan