The Board of Governors for Higher Education, State of Rhode Island and

Nzl Corporation

Thomas E Needham

Hossein Zia

Louis A Luzzi

Polireddy Dondeti

Emilio Squillante

Anita Nanda

Zia Hossein

Muhammad Quadir

The present invention describes a surprising new and effective pharmaceutical composition comprising microparticles and a pharmaceutically acceptable carrier. In particular, the present invention describes a pharmaceutical composition containing microparticles off a matrix material into which is infused a therapeutic agent. The present invention further provides a method of infusing a therapeutic agent such as a protein or peptide into a matrix material to form microparticles containing said therapeutic agent by employing a compressed solvent which is normally gaseous at ambient temperature and pressure. A method is also disclosed of treating or preventing a disease in a mammal by administering to said mammal through a mucosal membrane an effective amount of a pharmaceutical composition comprising microparticles containing a therapeutic agent which effectively treats the disease or disorder.

Method of incorporating proteins or peptides into a matrix and administration thereof through mucosa

A transdermal formulation of dihydropyridine calcium antagonists and specifically nifedipine, nimodipine and nitrendipine. The calcium antagonists are dispersed in a mixed liquid. The mixed liquid comprises varying mole fractions of cis-oleic acid and dimethylisosorbide dispersed in a polypropylene glycol base.

Transdermal delivery of calcium channel blockers, such as nifedipine

A pharmaceutical composition of a water soluble drug admixed with an aqueous bioadhesive cellulosic polymer containing microcrystalline particles. When sprayed (via a conventional spray device) into the nose, drug molecules are retained in contact with the nasal membrane. The drug composition comprises ketorolac tromethamine in an aqueous nasal polymeric spray formulation that without the addition of any permeation enhancer will promote drug absorption and provides absolute drug bioavailability greater than 90%.

Pharmaceutical compositions for intranasal spray administration of

Growing community of inventors

Wakefield, RI, United States of America

Thomas E Needham