The Ohio State University

Hendrix College

Other

Thomas E Goodwin

John C Byrd

Ola Elgamal

Mouad Abdulrahim

Chad E Bennett

Sandip Madhukar Vibhute

Erin Hertlein

Gary S Welch

Disclosed herein are compounds, 3,4,6,8-substituted-2-([1,1'-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Methods and compositions for inhibition of dihydroorotate dehydrogenase

Disclosed herein are compounds, 3,4,6,8-substituted-2-([1'-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

An expandable hunting arrowhead which ejects a signal generator and transmitter into the body of the quarry animal upon impact is described. The action of expanding blades, which rotate radially outwardly and backwardly to deploy from the sides of the arrowhead upon impact, separates the tip of the arrow containing the signal generator and transmitter in a sideways manner from the rest of the arrowhead. The sideways separation is obtained as a result of the rotating action of the blades, and the linear action of a plunger acted upon by the blades within the arrowhead. This way, the signaling tip is more likely to stay within the body of the animal, and not pass through it, to help the hunter locate the body.

Expandable arrowhead with sideways ejectable signal generator

Growing community of inventors

Conway, AR, United States of America

Thomas E Goodwin