Other

Spinal Restoration, Inc.

Genomyx, Inc.

Thomas E Davis

Sam L Austin

Henry L Schwartz

Douglas H Smith

Dean S Burgi

Alison M Grothe

Steven M VanHuystee

Steven Van Huystee

Brian J Mifsud

Danny G Morrow

John Gripp

The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.

Biological bioadhesive compositions and methods of preparation and use

Biological Bioadhesive composition and methods of preparation and use

The present invention relates generally to the preparation and use of novel enhanced biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen component in the presence of various critical biological and non-biological agents. The invention further relates to a novel method of using said enhanced fibrin sealant whereby the sealant and accompanying agent are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant resulting in enhanced therapeutic value derived by the prolonged presence, and optionally time-released delivery, of said accompanying agent at the critical site.

Biological bioadhesive composition and methods of preparation and use

This invention relates to the use of a unique apparatus and method for extracting radioactive components from liquids, such as electrophoresis buffers. In the present invention, the radioactive liquid is pumped or transported by other suitable means and is passed through a cartridge having an elongated chamber that contains an exchange medium. The exchange medium, i.e. exchange resin, is contained within the elongated chamber between an upper frit and a lower frit. Further, the cartridge has a means within the elongated chamber for retaining pressure between the upper frit and the lower frit. The nucleotides, being charged molecules, bind to the exchange medium and are removed from the liquid. The liquid then exits the cartridge and has such a low amount of radioactivity that it can be disposed of to a conventional drain.

Radioactive waste disposal cartridge

A gel electrophoresis separation apparatus comprising, in combination, a gaseous heat-exchange medium, a gaseous heat-exchange medium driving means, and an impingement means, whereby the gaseous heat-exchange medium is driven by the gaseous heat-exchange medium driving means across the impingement means to provide a flow of the gaseous heat-exchange medium on the surface of the gel plates, whereby the flow induced by passage of the gaseous heat-exchange medium through the impingement means thereby minimizes temperature gradients within the gel by forced convection.

Control of temperature gradients during gel electrophoresis using

This invention relates to isolating a DNA sample from a heterogeneous mixture of the DNA and other compounds. The invention relates in particular to isolating a plasmid DNA sample from a cleared bacterial lysate. The invention provides an apparatus and method for using the apparatus to rapidly and economically isolate a DNA sample from such a mixture without the use of hazardous chemicals.

DNA isolating apparatus comprising a non-porous DNA binding, anion

A laminated article comprising a plurality of abrasive resistant ceramic tiles secured to an elastomeric polyurethane cushioning support by means of a multitude of short thin fibers having major portions thereof embedded within an epoxy resin bonded to the tiles is fabricated by applying a thin layer of the resin in an uncured liquid phase to the tiles, applying a coating of the fibers to the liquid resin such that minor portions of the fibers in contact with the resin are wet thereby and the remaining major portions of the fibers extend from the resin layer, curing the resin to secure the fibers therein and to bond the resin to the tiles, applying a layer of a thermosetting polyurethane in an unpolymerized liquid phase to the fiber impregnated resin layer, and thereafter curing the polyurethane layer.

Abrasive resistant laminated article and method of manufacture

An aquarium tank having a bottom and four side walls is characterized by a transparent divider diagonally dividing the tank into two physically separate compartments, while maintaining the visual impression of a single compartment aquarium. The divider is vertical, rests on the bottom of the aquarium, and is of a height slightly greater than the level of water in the aquarium. The divider is clear and transparent throughout the major portion of the area thereof, and includes perforate areas adjacent its two ends for passage of water between the two compartments. Resilient mounting members at the two vertical ends of the divider provide a snug fit thereof into diagonally opposite corners of the aquarium. As a consequence of the physical separation of the compartments, newly born fry may be confined in one of the compartments safe from larger predatory fish in the other compartment.

Aquarium divider

A conveying chute for freshly mixed concrete is made from a metal frame having a replaceable polyurethane liner. The liner is formed flat about a porous metal reinforcement and is held in a curved trough defining shape by the frame.

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Kuna, ID, United States of America

Thomas E Davis