Raptor Pharmaceuticals Inc.

Raptor Therapeutics Inc.

Horizon Orphan LLC

Thomas E Daley

Michael S Tempesta

Elizabeth C Squiers

Kin-Hung Peony Yu

Kathy Powell

Olga Jarzebinski

Provided herein are methods, compositions and formulations to prevent or ameliorate ethanol intolerance, reduce or ameliorate symptoms associated with acetaldehyde accumulation accompanying ethanol consumption, or reduce the risk of diseases or disorders caused by acetaldehyde accumulation, comprising administering 4-MP, or physiologically acceptable salts thereof, to subjects with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity.

4-methylpyrazole formulations for inhibiting ethanol intolerance

Provided herein are 4-methylpyrazole (4-MP) formulations, stable under storage conditions of up to about 55&#xb0; C.

4-methylpyrazole formulations

Provided herein are ginsenoside compositions comprising at least 10% (w/w) of a protopanaxadiol type of ginsenoside suitable for administration to a subject. Also provided are methods using the ginsenoside compositions for reducing acetaldehyde concentrations, preventing or ameliorating a symptom of elevated acetaldehyde concentration, or reducing the risk of diseases or disorders caused by the intake of ethyl alcohol.

Protopanaxadiol-type ginsenoside compositions and uses thereof

Growing community of inventors

San Mateo, CA, United States of America

Thomas E Daley