Sartorius Stedim Biotech Gmbh

Thomas Dreher

Oscar-Werner Reif

Gerhard Greller

Ute Husemann

Oliver Scheibe

Thomas Loewe

Ralf Lausch

Thomas Friese

Paschalis Nikoloudis

Michael Gohs

Bjoern Nickel

Alexander Halt

Alexandre Espachs Barroso

Björn Nickel

A safety device for a single-use mixing or storage system (), especially for use in a biopharmaceutical process, includes a flexible bag () made from a film material and a support structure () receiving and supporting the bag () in several directions. The support structure () allows an expansion of the bag () in an expansion direction. The safety device further includes a detection unit () adapted to detect an expansion of the bag () in the expansion direction, and a control unit () connected to the detection unit () and adapted to initiate a safety measure in response to the expansion of the bag () in the expansion direction that exceeds a given threshold.

Safety device for a single-use mixing or storage system

A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.

Stirrer installation aid and method for installing a stirrer element in a bioreactor

The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.

Combined filter

A device and a method for adjusting stirring blades on a stirring blade receptacle of a stirrer, wherein the stirring blades can be fixed with a stirring blade axis in receiving bores, which are arranged transversely to an axis of rotation and are a part of the stirring blade receptacle, at intended predetermined angle of attack relative to a virtual plane that is arranged transversely to the axis of rotation of the stirrer. An associated device body is provided with a receiving element for receiving the stirring blade receptacle with unfixed stirring blades. A stop is arranged on the device body for each lower face, which faces the receiving element and is a part of the stirring blades, outside the respective stirring blade axis. Each respective stirring blade is then brought into abutment against its associated stop, to place it into the predetermined angle of attack.

Device and method for adjusting stirring blades

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Goettingen, Germany

Thomas Dreher