Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Thomas Dolbinow

Christoph Boehm

Sascha Lutz

Thomas Fischer

Juergen Spinke

Thorsten Brueckner

Eloisa Lopez-Calle

Josef Roedl

Thomas Manuel Keller

Erik Beiersdorf

Domenik Wensorra

Pamela Espindola

Sabrina Adler

A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.

Determining a quantity of an analyte in a blood sample

A cartridge for an automatic analyzer, formed from a cover and carrier structure, is operable for rotation about an axis and has at least one container with at least one reservoir containing at least one fluid. Each container may rotate about the axis within a cavity and relative to the carrier structure. A piercing structure opens a seal of each reservoir when the container rotates relative to the carrier structure. Each container and each cavity has a frictional element that mate and cause friction. Each container has an engaging surface which mates with an engaging surface of a rotational actuator that applies torque to rotate and open the container via the piercing structure. A fluidic structure of the cartridge processes a biological sample into a processed biological sample and enables via a measurement structure measurement of the processed biological sample. A duct is between the cavity and the fluidic structure.

Rotatable cartridge for measuring a property of a biological sample

Growing community of inventors

Dresden, Germany

Thomas Dolbinow