Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris

Sorbonne Université

Université Pierre Et Marie Curie (paris 6)

Université Paris Diderot-paris 7

Universite Paris Cité

Université Pierre Et Marie Curie

Université Paris Diderot

Inserm (institut National De La Sante Et De La Recherche Medicale)

Inserm

Thomas Deffieux

Mathieu Pernot

Mickaël Tanter

Jean-Luc Gennisson

Zsolt Lenkei

Mickael Tanter

Jean-François Aubry

Clément Papadacci

Ivan Cohen

Mickaél Tanter

Because of the increase of the obesity related diseases, it is desirable to be able to detect a fatty liver and quantify the content in fat for the fatty liver. Known methods are biopsy and magnetic resonance imaging. However, biopsy is an invasive method and magnetic resonance imaging is a complicated method to carry out. The inventors propose a new ultrasonic method, which is more compliant with a regular control of the content in fat for the fatty liver for a subject. This method notably relies on a smart exploitation of the coherence properties of ultrasound pulses applied to the liver. This method has already been validated on sane subjects as providing accurate measurements, notably for fat content.

Method for measuring the speed of sound in liver with a specific probe and associated methods and devices

The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising:

Multi-sensor brain detecting apparatus

The present invention aims at improving the Doppler imaging of a biological sample comprising blood. For this, it is proposed a method for imaging a biological sample (), the sample () comprising blood () comprising diffusors and solid tissue (), the method comprising obtaining observation, each observation being characterized by a different point spread function associating a signal to each location of the region of interest, the signal comprising a first contribution representative of the diffusors of blood vessels within the location, a second contribution representative of the tissue diffusors and a third contribution representative of blood signal associated to blood diffusors outside of the location, and estimating, for each location, the blood flow by using a statistical analysis.

Method for imaging a sample with blood and associated devices

The invention relates to a method for obtaining a numerical model, the numerical model associating at least one objective measurement to a subjective sensation, the method comprising the steps of: a) imaging the at least one area of the brain by using unfocused waves produced by a transcranial ultrasound probe (), to obtain at least one acquired image of the activity of the area, b) evaluating a physical quantity representative of the activity of the at least one area based on the acquired images, to obtain at least one objective measurement, c) obtaining from the subject at least one numerical value representative of a subjective sensation, and d) determining the numerical model by using the obtained objective measurement and the obtained numerical value.

Method for obtaining a numerical model associating an objective measurement to a subjective sensation using ultrasound imaging technique and associated device

The invention concerns a detecting apparatus () comprising:&#x2014;at least two sensors (), with at least one sensor () being an ultrasound transducer adapted to produce ultrasound waves, and&#x2014;a positioning device () defining several compartments (), each compartment () being adapted to hold a sensor () and each compartment () being located at predetermined location, the positioning device () comprising a holder adapted to be fixed on the skull of a subject, the positioning device () being adapted to be maintained on the head of the subject using the holder.

Detecting apparatus and associated kit and method

In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.

Insonification method for obtaining a predetermined field of ultrasonic waves and production method for making an ultrasonic lens for these purposes

The invention concerns a detecting apparatus () for imaging at least two areas of a brain of a subject (), the detecting apparatus () comprising: &#x2014;a holder comprising: &#x2014;a frame () devoted to be cemented on the skull of the subject (), the frame () delimitating an inner portion () which is transparent to ultrasound waves, &#x2014;a removable imaging device comprising: &#x2014;a platform () delimitating an inner space (), the inner space () facing the inner portion (), &#x2014;a fixing element () adapted to temporary fix and lock the platform () to the holder, &#x2014;an ultrasound probe (), and &#x2014;a moving stage () holding the ultrasound probe () and being adapted to move the ultrasound probe () within the inner space ().

Detecting apparatus and associated imaging method

Method for functional imaging of the brain, comprising the following steps: (a) a brain is imaged by ultrasound imaging in order to obtain a vascular image to be studied (IVO), (b) the vascular image to be studied (IVO) is compared automatically, by shape recognition, with a cerebral vascular atlas (AV), and the vascular image to be studied (IVO) is thus located in the cerebral vascular atlas (AV), (c) a cerebral functional atlas (AF) corresponding to said cerebral vascular atlas (AV) and comprising cerebral functional zones () located in this cerebral vascular atlas (AV) is used in such a way as to identify cerebral functional zones () on the vascular image to be studied (IVO).

Growing community of inventors

Paris, France

Thomas Deffieux