University of Michigan

Other

Leland Stanford Junior University

Thomas D Wang

Brian A Horowitz

Xiyu Duan

William F Ryczek

Kenn Oldham

Haijun Li

Bishnu P Joshi

Juan Zhou

Zhen Qiu

Gaoming Li

Katsuo Kurabayashi

Jing Yong Ye

Supang Khondee

Mitchell Weiss

Zhao Li

Emily Rabinsky

Mayur Bhushan Birla

Sharon Miller

Jongsoo Choi

Zhongyao Liu

Shaoying Lu

A compact single-axis confocal endomicroscope is provided, capable of complying within 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing a high numerical aperture that allows for diffraction-limited resolution with sub-surface depths. The scanning mirror is formed on a fixed-position, scanning MEMS assembly and has a central aperture that allows for illumination beam expansion in the folded path design. A series of spacers are used to retain beam focusing optical elements in fixed positioned relative to the scanning MEMS assembly for coupling with a single mode fiber.

Ultra-compact microsystems-based single axis confocal endomicroscope

A scanning assembly for an optical instrument includes a reflector and a folded-beam spring assembly coupled to the reflector for deflecting the reflector for beam scanning. A lever suspension assembly is coupled to the folded-beam spring assembly and provides torsional movement of the reflector for beam scanning over a two-dimensional region, allowing for large total scan angles and large vertical displacements.

Comb-driven MEMS resonant scanner with full-circumferential range and large out-of-plane translational displacement

A compact single-axis confocal endomicroscope is provided, capable of complying with 2.8 mm diameter endoscope space requirements. The single-axis confocal endomicroscope uses a folded path design achieved between a fixed mirror and a lateral plane scanning mirror thereby producing high numerical apertures that allow for diffraction-limited resolution in sub-surface scanning. The scanning mirror has a central aperture that allows for illumination beam expansion in the folded path design.

Ultra-compact folded-beam path confocal endomicroscope

A computer-implemented method includes receiving a raw data set representing an image of a sample, identifying a first set of extremum by analyzing the raw data set using a metric algorithm, identifying a second set of extremum by analyzing the first set of extremum, and generating, based on the second set of extremum, a reconstructed image of the sample. A phase correcting scanner includes one or more processors, one or more scanner adapted to sequentially sample an object to generate a vector of raw data representing the object in a Lissajous pattern, and memory storing instructions that, when executed by the one or more processors, cause the computing system to receive the vector of raw data, identify a first set of extremum by analyzing the raw data set using a metric algorithm, and identify a second set of extremum by analyzing the first set of extremum.

Phase detection and correction using image-based processing

Wheel

A wireless digital treatment and warning system for veterinarian animal cages includes software that reads stored data for a course of treatment and prescription medication information for a particular animal in a particular cage, identifies the unique veterinarian animal cage number for the particular animal, identifies a digital display panel number paired with the unique veterinarian animal cage number for the particular animal, visually outputs digitized treatment information for the particular animal in time-synchronized accordance with the course of treatment and prescription medication information for the particular animal, and triggers the colored warning lights to activate as a visual warning alert to feed, medicate, or take care of the particular animal.

Wireless digital treatment and warning system and display for veterinarian animal cages

An optical probe assembly as a confocal endomicroscope includes an optical focusing stage that focuses an output beam onto a sample and a mirror scanning stage that is movable for scanning the output beam in both a lateral two dimensional plane and an axial direction, using a side-view configuration. The side-view configuration allows for output beam illumination and fluorescent imaging of the sample with greater imaging resolution and improved access to hard to reach tissue within a subject.

3-axis side-view confocal fluorescence endomicroscope

The present disclosure relates to Fibroblast Growth Factor Receptor 2-specific peptide reagents, methods for detecting epithelial-derived cancer cells such as esophageal, colorectal, gastric, pancreatic or breast carcinoma cells using the peptide reagents, and methods for targeting such cells using the peptide reagents.

Fibroblast growth factor receptor 2-specific peptide reagents and methods

An apparatus configured to convert between a cart and a lounge chair comprising a bottom portion, backrest portion, a leg rest portion, first and second removable side portions. The backrest and leg rest potions rotatably coupled to the bottom portion and movable between open and upright positions. The first and second removable side portions being coupled to the backrest and leg portions when in the upright positions, wherein an open carton of the cart is formed by the bottom portion and the leg rest and backrest portions when in the upright positions, and the first and second removable side portions when connected to the leg rest and backrest sides, and the leg rest and backrest portions, when in the outward positions, form a seat, a leg rest and a backrest of the lounge chair, respectively, the lounge chair being configured to support a person in a sitting or lounging position.

Lounge cart

The present invention is directed to glypican-3-specific peptide reagents, methods for detecting hepatocellular carcinoma cells using the peptide reagents, and methods for targeting hepatocellular carcinoma cells using the peptide reagents.

Glypican-3 peptide reagents and methods

The present invention relates to micelle drug carriers and methods of using the micelles to deliver drugs to target cells. The micelles are useful, for example, for carrying and targeting drugs for the treatment of cancer to cancer cells. As one example, the disclosure provides pegylated octadecyl lithocholate micelles that are labeled with a peptide ligand for colorectal neo-plasia and that carry the small molecule mTOR inhibitor rapamycin to colorectal cancer cells.

Growing community of inventors

Ann Arbor, MI, United States of America

Thomas D Wang