Zafgen, Inc.

Other

Cerulean Pharma Inc.

Thomas Crawford

Hayley A Reece

J Michael Ramstack

David Jon Am Ende

Neil P Weston

The disclosure is in part directed to crystalline forms of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol and variants thereof.

Crystalline solids of a metAP-2 inhibitor and methods of making and using same

Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., &#x3b1;-cyclodextrin, &#x3b2;-cyclodextrin, and &#x3b3;-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.

Methods and systems for polymer precipitation and generation of particles

Crystalline solids of a MetAP-2 inhibitor and methods of making and using same

The disclosure is in part directed to crystalline forms of an oxalate salt of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol.

Polymorphic salt of a metap-2 inhibitor and methods of making and using same

A pet transporter that can be towed behind a wheeled vehicle is disclosed. The pet transporter comprises a carrier member, a frame adapted to receive the carrier member, a pair of side bows attached to the side walls of the carrier and to the frame, a pair of wheel assemblies attached to the frame on opposite sides of the carrier, and an attachment arm with a first end and a second end, wherein the first end is adapted to be attached to the frame proximate the front wall of the carrier and the second end is adapted to releasably attach to a rear axle of a wheeled vehicle. The pet transporter has a low center of gravity, making tipping of the pet transporter more difficult. In addition, few tools are required to assemble and disassemble the pet transporter.

Pet transporter

This invention provides a method of conducting a simultaneous chemical reaction and controlled crystallization of the product employing impinging fluid jet streams containing reactants capable of producing the product with desired particle size characteristics.

Growing community of inventors

Essex, CT, United States of America

Thomas Crawford