Life Technologies Corporation

Thomas Conner

Michael C Pallas

Chee Kiong Lim

Chee Wee Ching

Janusz B Wojtowicz

Geoffrey Dahlhoff

Douglas W Grunewald

A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

Thermal uniformity for thermal cycler instrumentation using dynamic control

The present teachings disclose various embodiments of a thermal block assembly having low thermal non-uniformity throughout the thermal block assembly. Accordingly, various embodiments of thermal block assemblies having such low thermal non-uniformity provide for desired performance of bioanalysis instrumentation utilizing such thermal block assemblies.

Thermal block assemblies and instruments providing low thermal non-uniformity for rapid thermal cycling

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Mountain View, CA, United States of America

Thomas Conner