Baseclick Gmbh

Roche Diagnostics Operations, Inc.

Basf Aktiengesellschaft

F. Hoffmann-la Roche Ag

Thomas Carell

Anja Schwögler

Glenn Ashley Burley

Johannes Gierlich

Mohammad Reza Mofid

Dieter Heindl

Uwe Kobold

Andreas Leinenbach

Martin Rempt

Silvia Baecher

Toni Pfaffeneder

Angie Kirchner

Olesea Kosmatchev

Rene Rahimoff

Sarah Schiffers

Markus Muller

Anja Schwoegler

The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

Reagent for mass spectrometry

The present disclosure relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of the reagents and adducts. Further, the present disclosure relates to methods for the mass spectrometric determination of analyte molecules.

Sulfoxide-based reagent for mass spectrometry

The present invention refers to the transfection of cells using a conjugate comprising at least one saccharide residue at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of prokaryotic and eukaryotic cells such as plant cells or mammalian cells including human cells with high efficacy. Thus, a new delivery vehicle for therapeutic molecules including antisense molecules, sRNA molecules, miRNA molecules, antagomirs or precursors of such molecules, as well as the therapeutic nucleosides or nucleotides, is provided. Further, a convenient strategy for developing new lines of plants that exhibit particular traits is provided.

Saccharide-modified nucleic acid molecules

The present invention refers to a conjugate comprising at least one polyunsaturated fatty acid residue, particularly an arachidonic acid residue, more particularly an anandamide (arachidonoyl ethanol amide) residue and covalently bound thereto at least one nucleosidic component selected from nucleic acids, nucleosides and nucleotides. This conjugate is suitable for the transfection of cells such as mammalian cells including human cells with high efficacy. Thus, a new delivery vehicle for therapeutic molecules including antisense molecules, siRNA molecules, miRNA molecules, antagomirs or precursors of such molecules, as well as the therapeutic nucleosides or nucleotides, is provided.

Anandamide-modified nucleic acid molecules

The present invention relates to methods and reagents for detecting analytes, e.g. nucleic acids. The new methods and reagents allow a simple and sensitive detection even in complex biological samples.

Labelling strategies for the sensitive detection of analytes

The present invention relates to methods for producing reporter molecules suitable for the detection of analytes, e.g. nucleic acids. Further, the present invention relates to methods and regions for detecting analytes.

Click chemistry for the production of reporter molecules

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Krailling, Germany

Thomas Carell