Mayo Foundation for Medical Education and Research

Thomas C Wood

Richard M Weinshilboum

Ibrahim A Aksoy

Eric D Wieben

Diane M Otterness

Bianca A Thomae

Rebecca B Raftogianis

Ronald Honchel

Carol L Szumlanski

Isolated ASMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as ASMT allozymes. Methods for determining if a mammal is at risk for toxicity from acute or chronic arsenic exposure also are described.

Arsenic methyltransferase sequence variants

Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described. Methods for determining a risk estimate for hormone dependent disease and methods for determining sulfonator status also are described.

Sulfotransferase sequence variants

The present invention provides an isolated and purified human DNA molecule that encodes human estrogen sulfotransferase.

cDNA cloning and expression of human liver estrogen sulfotransferase

The present invention provides an isolated and purified human DNA molecule consisting essentially of a DNA segment encoding an estrogen sulfotransferase protein or biologically active derivative thereof.

A recombinant DNA sequence is provided which encodes human thiopurine methyl transferase (TPMT), as well as a mammalian cell line having said recombinant DNA sequence incorporated into the genome thereof, so that the cells express high levels of human TPMT activity.

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Rochester, MN, United States of America

Thomas C Wood