Polydex Pharmaceuticals Limited

Rush-presbyterian-st. Luke's Medical Center

Other

The University of British Columbia

Dextran Products Limited

Thomas C Usher

Robert A Anderson

Lourens J D Zaneveld

Natu Patel

Lourens Jan Zaneveld

David P Speert

Simon H Wallis

Izu Hattori

Chhagan G Tele

The invention relates to the treating, inhibiting or preventing of certain infectious agents including papilloma virus and various vaginitis-causing microbes by employing cellulose sulfate and other sulfated polysaccharides. In one embodiment, the method involves preventing, inhibiting or treating fungal infections. Corresponding methods of use in manufacturing a medicament as well as use in preventing and inhibiting various infectious agents as well as malignant lesions are disclosed. In another embodiment, use of a sulfated polysaccharide in preventing, inhibiting or treating a parasitic infection is disclosed.

Cellulose sulfate and other sulfated polysaccharides to prevent and treat papilloma virus infection and other infections

A method for treating and preventing various infections, including papilloma virus and fungal and parasitic infections is provided. In particular, an effective amount of a sulphated polysaccharide, such as cellulose sulphate and dextran sulphate are administered to prevent and treat these infections. The invention also relates to use of these compounds for the prevention and inhibition of malignant epithelial lesions associated with papilloma virus, such as cervical cancer.

A method for treating and preventing various infections, including papilloma virus and fungal and parasitic infections is provided. In particular, an effective amount of a sulfated polysaccharide, such as cellulose sulfate and dextran sulfate are administered to prevent and treat these infections. The invention also relates to use of these compounds for the prevention and inhibition of malignant epithelial lesions associated with papilloma virus, such as cervical cancer.

The present invention provides a process of preparing a novel carboxylic acid derivative of dextran. In particular, in the present invention, carboxylated dextran containing at least one carboxylic acid is reduced to remove all or substantially all reducing groups.

Process of making carboxylated dextran

The present invention relates to a method of reducing the risk of infections and the risk of conception. In particular, the invention relates to cellulose sulfate having contraceptive and anti-microbial properties. Cellulose sulfate may be administered in appropriate dosage forms to reduce the risk of infections or the risk of conception. It can also be used during sexual contact to concomitantly reduce the risk of conception and the risk of sexually transmitted diseases.

Cellulose sulfate for use as antimicrobial and contraceptive agent

Methods for reducing the risk of or preventing infections by bacterial pathogens in vivo. In particular, a method for reducing the risk of P. aeruginosa infection in vivo in compromised hosts such as cystic fibrosis patients. The methods involve the use of dextran or dextran sulphate as the active ingredient.

Method of preventing or reducing the risk of infection by bacterial

The present invention provides a process for the preparation of water soluble alkali metal salts of cellulose sulfate having a degree of substitution ranging from 1 to 3 and viscosity of 1 percent aqueous solution in excess of 20 centipoises (cps). The process involves the use of chlorosulfuric acid as a sulfonating agent in the presence of pyridine used as a solvent in reaction. The important steps of the process for preparation of the water soluble salts include presoaking of the cellulose in pyridine followed by washing the pyridine salt with an alcohol such as methanol and reacting saturated alkali metal bicarbonate or carbonate solutions with the sulfonated cellulose.

Process for preparing soluble alkali metal salts of cellulose sulfate

A method for the preparation of dextran sulfate and salts thereof which comprises first forming a complex between sulfur trioxide and formamide at a controlled temperature between 15.degree.-40.degree. C. in the presence of dry nitrogen gas and thereafter reacting said complex with dextran at a controlled temperature between 25.degree.-55.degree. C.

Method for the manufacture of dextran sulfate and salts thereof

Cosmetic preparations comprising water soluble fatty acid amide derivatives of hydrolyzed collagen are found to have a substantial degree of permeability to the stratum corneum of human skin and to be effective in improving skin texture, moisture retention and minimizing wrinkles.

Skin treatment compositions and method of use thereof

This invention relates to a cosmetic preparation which comprises novel derivatives of solubilized elastin which are fatty acid amides of elastin, and which have been found to permit deeper penetration and a higher percentage absorption of elastin into the stratum corneum of human skin.

Cosmetic preparations comprising novel elastin derivatives

This invention relates to an improved process for the manufacture of diethylaminoethyl dextran (DEAE dextran) and the diethylaminoethyl derivative of hydrogenated dextran (DEAE hydrodextran). A product of greater purity and improved color is obtained by the addition of a borohydride, such as sodium borohydride during manufacture to generate hydrogen in situ during the reaction.

Manufacture of diethylaminoethyl dextrans

The present invention relates to novel dextran derivatives having a plurality of carboxylic acid groups positioned upon intermediate glucose or glucopyranose units of the dextran polymer, and substances formed therefrom by complexing or chelation with colloidal ferric hydroxide to produce stable products of low intravenous toxicity and containing a relatively high iron content. It further relates to a process for producing said polycarboxylic acid compounds as well as the ferric hydroxide complexes described.

Growing community of inventors

Nassau, Bahamas

Thomas C Usher