Biopure Corporation

Other

Thomas C Page

William Richard Light

Edward E Jacobs, Jr

Jose O Torres

A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.

Method of forming a polymerized hemoglobin solution from stabilized hemoglobin

A method of treatment of a patient includes administering to the patient stored red blood cells and a hemoglobin solution. The stored red blood cells and the hemoglobin solution can be administered to the patient simultaneously. Alternatively, the hemoglobin solution can be administered to the patient prior to administrating the stored red blood cells or the stored red blood cells can be administered to the patient prior to administering the hemoglobin solution. A composition of the invention includes stored red blood cells and a hemoglobin solution.

Method for improving oxygen transport by stored red blood cells

A system and method are provided to monitor a patient's respiration during and after medical/surgical procedures, as well as in clinical situations wherein the patient is at increased risk for developing central or obstructive respiratory depression and/or apnea. A sensor attached to the patient's face, which monitors nasal and oral air-flows. An electronic monitor analyzes patient respiratory patterns and initiates bedside and/or remote nursing station alarms in real time if and when a clinically significant respiratory event is detected. Respiration is measured by monitoring changes in the acoustic signature of the patient's breath passing over a corrugated or uneven surface, changes in the pressure of an inflatable closed volume of a sensor caused by the changes in temperature of the interior volume caused by the patient breathing over the sensor, or both.

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Watertown, MA, United States of America

Thomas C Page