Neonc Technologies, Inc.

Speedlink Technology Inc.

University of Southern California

Georgia Tech Research Corporation

Pharmaco-kinesis Corporation

Swiftlink Technologies Inc.

Cognos Therapeutics Inc.

Swiftlink Technologies Co., Ltd.

Other

Sensor Kinesis Corporation

Orion Spine Inc.

Neone Technologies, Inc.

Johnson; David

Shachar, Yehoshua

Chen, Thomas

Thomas C Chen

Daniel Levin

Taiyun Chi

Yehoshua Shachar

Hua Wang

Satish Puppali

Satish Pupalli

Leslie Farkas

Min-Yu Huang

Winston Wu

Laszlo Farkas

Bruce Marx

David Johnson

Che-Chun Kuo

Kyle Zimmerman

Chad Srisathapat

Thomas Jay Lobl

Virote Indravudh

Brett LeBeau Jordan

Allan R Schwartz

Juan Ramon Gonzalez

Christian Merot

Florence M Hofman

Herwin Chan

Jeffrey A Brydle

Jean C Shih

Paladin Luboff

Nicos A Petasis

Daniel A Dickman

Josh Shachar

Stan G Louie

Ming-Fu Chiang

Gilberto Schwartsmann

Doohwan Jung

Clovis O Da Fonseca

Thereza Quirico Dos Santos

Dongxu Chen

Roger D Kornberg

Kevin P Armstrong

Huy Thong Nguyen

Axel H Schonthal

Satish Puppalli

Moran Cerf

Axel H Schönthal

Conway T Chen

Florence M Hoffman

Sensen Li

Lazlo Farkas

The present invention provides for a perillyl alcohol (POH) carbamate, such as POH-Rolipram. The present invention also provides for a method of treating a disease such as cancer, by delivering to a patient a therapeutically effective amount of POH-Rolipram.

Pharmaceutical compositions comprising POH derivatives

The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.

Methods of permeabilizing the blood brain barrier

The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

Pharmaceutical compositions comprising monoterpenes

A skull-mounted drug and pressure sensor (SOS), a smart pump (ISP) electrically coupled to the SOS and a drug delivery and communications catheter communicating the SOS with the ISP are combined for a first embodiment. A skull-mounted (SOS), a metronomic biofeedback pump (MBP) electrically coupled to the SOS and a drug delivery and communications catheter having a sending and receiving optical fiber communicating the SOS with the MBP are combined for a second embodiment. A third embodiment combines a (SOS), an implantable power and communication unit (PCU) electrically coupled to the SOS, and a drug delivery and communications catheter for communicating the SOS with the PCU and for communicating the exterior source of the drug to the SOS. A fourth embodiment combines a ventricular catheter with a CSF accessible chamber and drug delivery port; and an implantable stand-alone skull-mounted drug and pressure sensor (SPS).

Skull-mounted drug and pressure sensor

The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.

Methods of treating neurofibromatosis with perillyl alcohol

According to one embodiment, a transformer-based in-phase and quadrature (IQ) includes a differential balun having a first inductor and a second inductor. The first inductor has a first input terminal and a first output terminal. The second inductor has a second input terminal and a second output terminal. Additionally, the IQ generator circuit includes a third inductor magnetically coupled with the first inductor. The third inductor has a first isolation terminal and a third output terminal. The IQ generator circuit also includes a fourth inductor magnetically coupled with the second inductor. The fourth inductor has a second isolation terminal and a fourth output terminal. The IQ generator circuit additionally includes a first transistor coupled to the first input terminal of the first inductor. Further, the generator circuit includes a second transistor coupled to the second input terminal of the second inductor. The first transistor, the second transistor, the first inductor, and the second inductor form a part of a differential amplifier.

Transformer-based current-reuse amplifier with embedded IQ generation for compact image rejection architecture in multi-band millimeter-wave 5G communication

A surgical kit includes a shield for covering a portion of the spine of a subject. The shield can include an attachment portion adapted to engage a bone fixation assembly which is adapted to be fixed on multiple vertebra bones of the subject. The bone fixation assembly can include a vertebra joining member secured between two bone anchors. Each bone anchor can include a fastener portion adapted to be implanted into a vertebra bone and a head coupling portion adapted to secure the vertebra joining member. The shield can be coupled to the bone fixation assembly via separate coupling elements, such as a clip or an adjustable link secured between two vertebra joining members of the bone fixation assembly. Alternatively, the shield can include an integral attachment portion configured to engage the bone fixation assembly directly.

Spine protection device

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of a perillyl alcohol derivative such as a perillyl alcohol ester, or an isoperillyl alcohol derivative such as an isoperillyl alcohol ester. The derivative may be a perillyl alcohol or an isoperillyl alcohol conjugated with a therapeutic agent such as valproic acid. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

Pharmaceutical compositions comprising POH derivatives and methods of use

An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.

Apparatus and method for cerebral microdialysis to treat neurological disease, including Alzheimer's, Parkinson's or multiple sclerosis

A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.

Pharmaceutical compositions comprising perillyl alcohol derivatives

According to one embodiment, an RF frontend IC device includes a first RF transceiver to transmit and receive RF signals within a first frequency band and a second RF transceiver to transmit and receive RF signals within a second frequency band that is different than the first frequency band. The RF frontend IC device further includes a converter and a multi-band local oscillator (LO) generator to provide LO signals to the converter. The multi-band LO generator includes a phase-lock loop (PLL) circuit operating at a PLL operating frequency, wherein the PLL operating frequency is outside of the first frequency band and the second frequency band. The multi-band LO generator also includes multiple frequency multipliers coupled to the PLL circuit to upscale the PLL operating frequency and to generate an LO signal having a frequency within a predetermined proximity from the frequency band.

Scalable dual-polarization mm-wave multi-band 5G phased array with a multi-multipliers LO generator

There is provided wireless transmitter that includes a poly phase filter (PPF) configured to receive an input differential intermediate frequency (IF) signal and to generate an in-phase differential IF signal and a quadrature differential IF signal. The wireless transmitter further includes a transformer-based circuit configured to receive an input differential local oscillator (LO) signal and to generate an in-phase differential LO signal and a quadrature differential LO signal based on the input differential LO signal. In addition, the wireless transmitter includes a mixer configured to multiplicatively mix the in-phase differential IF signal with the quadrature differential LO signal to produce a first RF signal component and to multiplicatively mix the quadrature differential IF signal with the in-phase differential LO signal to produce a second RF signal component, the mixer further configured to provide a differential RF signal comprising a (filtered or unfiltered) combination of the first RF signal component and the second RF signal component. Furthermore, the wireless transmitter includes an amplification stage configured to amplify the differential RF signal, the amplification stage comprising a driver stage and a power amplifier stage.

Wideband transmitter for millimeter-wave wireless communication

According to one embodiment, an RF frontend IC device includes a first array of transceivers to transmit and receive RF signals of a first polarization associated with a first set of RF channels. The device includes a second array of transceivers to transmit and receive RF signals of a second polarization associated with a second set of RF channels. The device includes a first converter coupled to each transceiver of the first array of transceivers and a second converter coupled to each transceiver of the second array of transceivers. The first converter is to up-convert or down-convert a signal of the first polarization based on a LO signal. The second converter is to up-convert or down-convert a signal of the second polarization based on the LO signal. The first and second array of transceivers, and the first and second converters may be implemented within a single IC chip.

Dual polarization millimeter-wave frontend integrated circuit

Growing community of inventors

La Canada Flintridge, CA, United States of America

Thomas C Chen