Massachusetts Institute of Technology

Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Affinity Biosensors, LLC

Thomas Burg

Scott R Manalis

Kenneth Babcock

Michel Godin

Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

Method and apparatus for measuring particle characteristics through mass detection

An ultra-rapid freezing device () adapted for cooling a sample (), includes a substrate chip () being adapted for cooling the sample (), and at least one sample carrier () being adapted for accommodating the sample () and including at least one heatable support (), through which the at least one sample carrier () is attached to the substrate chip (). Preferably, the at least one sample carrier () is attached to the substrate chip () in a suspended manner. Furthermore, a method of ultra-rapid freezing a sample () is described. The at least one sample carrier () can be switched between a heated state at which a thermal gradient is formed relative to the substrate chip () and a cooled state at which a thermal equilibrium is formed relative to the substrate chip ().

Ultra-rapid freezing device and method

An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The apparatus also includes at least one detector for measuring a change in the beam upon binding or reaction of the analyte. A method of making the suspended microfluidic channels is disclosed, as well as, a method of integrating the microfluidic device with conventional microfluidics having larger sample fluid channels.

Growing community of inventors

Cambridge, MA, United States of America

Thomas Burg