Apatech Limited

The University Court of the University of Aberdeen

Thomas Buckland

Charles Campion

Iain Ronald Gibson

Nigel G Smith

Janet Mabel Scott Skakle

Janet M S Skakle

Daniel J Hadden

Paul Kearsley

Jonathan Arcos

Qian Cai

Mervyn Little

James J Cassidy

Iain R Gibson

Nigel Smith

Janet Mabel Scott 48 Glenury Crescent Skakle

Iain Ronald 48 Glenury Crescent Gibson

Jennifer Anne 28 Seaview Drive Stephen

A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: CaGd(PO)(SiO)x(OH)where 0&#x3c;x&#x3c;1.3 and 0&#x3c;y&#x3c;1.3.

Biomedical materials

A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.

Porous biomaterial

A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprise a compound having the general chemical formula: CaGd(PO)(SiO)x(OH)where 0&#x3c;x&#x3c;1.3 and 0&#x3c;y&#x3c;1:3.

A biocompatible material comprising a resorbable polymer matrix and at least one additive, wherein the resorbable polymer matrix comprises: (i) at least one non-random copolymer of poly (alkylene oxide) s, and (ii) at least one poly (alkylene glycol) polymer and/or at least one methoxypoly (alkylene glycol) polymer, and wherein the at least one additive is selected from solid particles, porous particles, hollow particles, polymers, inert fillers, bioactive compounds, color pigments and combinations of two or more thereof.

Biomaterial

A bone replacement filler comprising a biomedical ceramic particulate, wherein the filler is able to flow without the application of an external shear stress or compressive force or under a relatively low shear stress or compressive force, but resists flow or does not flow when subjected to a higher shear stress or compressive force, and wherein at least some of the particles in the ceramic particulate have a micro-porous surface structure and/or a micro-porous sub-surface structure.

Biomedical filler

A bone graft material is provided comprising granules of synthetic bone material, at least some of which have a solid coating comprising a blood-clotting agent. A device for delivering bone-replacement material to a an area to be treated is also provided, the device comprising: a chamber for containing bone-replacement material, wherein the chamber is pre-loaded and/or pre-coated on an interior surface thereof with a blood-clotting agent; means for introducing bone-replacement material into the chamber to contact the blood-clotting agent; and a means for delivering the bone-substitute material from the chamber to the area to be treated.

Bone-replacement materials, methods and devices

The present invention provides a process for the preparation of a silicate and carbonate co-substituted calcium phosphate material. The process comprises the steps of: forming a silicon and optionally carbon-containing calcium phosphate precipitate by an aqueous precipitation method involving preparing an aqueous solution comprising phosphate ions, silicate ions, calcium ions and optionally carbonate ions, wherein the ratio of Ca/P and of Ca/(P+Si) in the solution is maintained above approximately 1.67; and heating the precipitate in an atmosphere comprising carbon and oxygen to form a silicate and carbonate co-substituted calcium phosphate material. The present invention also provides a synthetic carbonate and silicate co-substituted hydroxyapatite material, as well as a biomedical material.

A delivery device for semi-solid implantable material such as synthetic bone graft substitutes. The device includes a handle, a cylinder extending from the handle and having an outlet at its distal end. A piston is operated by a trigger and is slidable within the cylinder to displace the material from the cylinder. The cylinder has a substantially constant inner diameter along its entire length such that the outlet has substantially the same inner diameter as the rest of the cylinder. When the trigger is fully depressed, a ratchet mechanism is disengaged allowing the piston to be pulled back to a starting position.

Dispensing instrument

The present invention provides a synthetic non-resorbable silicon-containing calcium phosphate biomaterial having a microporosity of 23% by volume or greater, wherein the surface free energy of the biomaterial is 19 mJ/m.

Porous biomaterial on hydroxyapatite

A delivery device for semi-solid implantable material such as synthetic bone graft substitutes. The device comprises a handle (), a cylinder () extending from the handle and having an outlet at its distal end. A piston () is operated by a trigger () and is slidable within the cylinder to displace the material from the cylinder. The cylinder has a substantially constant inner diameter along its entire length such that the outlet has substantially the same inner diameter as the rest of the cylinder. When the trigger is fully depressed, a ratchet mechanism () is disengaged allowing the piston to be pulled back to a starting position.

Growing community of inventors

Aylesbury, United Kingdom

Thomas Buckland