Roehm Gmbh & Co Kg

Thomas Boller

Hans-Ulrich Petereit

Christian Meier

Thomas Suefke

Roger Recktenwald

Stefan Menzler

Klaus Schultes

The invention relates to a macroporous plastics bead material with an average particle diameter from 10 to 1000 &#x3bc;m, containing a copolymer of a) 5-60 wt. % vinylically polymerizable monomers with a water solubility of at least 1% at 20&#xb0; C., b) 1-40 wt. % vinylically polymerizable monomers with an additional functional group, which can enter into covalent bonds with the nucleophilic groups of the ligands in a polymer-like reaction, c) 10-40 wt. % hydrophilic, crosslinking radical-polymerizable monomers with two or more ethylenically unsaturated polymerizable groups and d) 10-60 wt. % vinylically polymerizable monomers with a water solubility of at most 1% at 20&#xb0; C. are contained, as a rule with the monomers a) to d) adding up to 100%.

Macroporous material in the form of plastic pearls

The invention relates to a process for the preparation of cephalexin with the aid of a penicillin amidase immobilized on a crosslinked hydrophilic copolymer which has binding activity for ligands having nucleophilic groups and is in bead form.

Method for producing cephalexin

The invention relates to a process for synthesis, by inverse bead polymerization of a monomer phase, of a bead-like, cross-linked, hydrophilic copolymer which has binding activity toward ligands containing nucleophilic groups. The invention relates to support polymer materials with high binding capacity for penicillin acylase and low swelling factor, as well as to use of the same.

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Darmstadt, Germany

Thomas Boller