Nimbus Biotechnologie Gmbh

Thomas Bayerl

Gero Decher

Angelika Loidl-Stahlhofen

Thomas Braunschweig

Matthias Schoettner

The invention relates to the analysis of interactions of substances or materials with surfaces or interfaces made from amphiphilic materials and in particular partition coefficients and/or binding constants are determined. For this purpose use is made of a carrier material, which is so coated with amphiphilic molecules in the so-called fluid phase that the lateral diffusion of the amphiphilic molecules is substantially unimpeded. The invention also relates to a kit suitable for such analyses, and to a process for analyzing these interactions in column chromatography, particularly high pressure or performance liquid chromatography.

Interactions between substances and surfaces that are made up of amphiphilic molecules

A two-dimensional patterning of a three-dimensional surface by a template molecule (or object) involving non-covalent interactions between the template and the surface and the reversible fixation of the pattern by undergoing a phase transition in the patterned material. In this invention the surface provides a multitude of mobile functional groups (matrix) which are spatially arranged by the interaction with the template, the template selects and arranges only those groups out of a multitude of functional groups which allow for a maximum of interaction between the template and the surface. The resulting pattern is then stabilized by reducing the mobility of all functional groups present on the surface by undergoing a phase transition to a state of high surface viscosity. After separation of the template and the patterned surface, the pattern on the surface is used for recognition, separation or catalytic purposes.

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Wuerzburg, Germany

Thomas Bayerl