Hoechst Aktiengesellschaft

Thomas Bayer

Joachim Wink

Hans-Matthias Deger

Klaus Sauber

Rainer Buchholz

Uwe Wirth

Ulrich Holst

Microwave heating of intact Trigonopsis variabilis cells to 60.degree.-68.degree. C. for 20-40 seconds selectively deactivates esterases and catalases while retaining the activity of D-amino acid oxidase. The heating is effected with a microwave frequency of 0.4-24 GHz.

Process for the selective deactivation of esterases and catalases in

A process for the continuous conversion of cephalosporin derivatives into glutaryl-7-aminocephalosporanic acid derivatives A process for the continuous conversion of cephalosporin derivatives into the corresponding glutaryl-7-aminocephalosporanic acid derivatives in the presence of a catalyst containing D-amino-acid oxidase is described. The product yield can be increased, where appropriate, by addition of hydrogen peroxide.

Process for the continuous conversion of cephalosporin derivatives into

The invention relates to a process for the preparation of colorants and/or active compounds by culturing a microorganism of the genus Monascus in a sterilizable fluidized-bed fermenter of low water content, such as was proposed in German Patent Application P 3,625,698.6. The fluidizable particle used here is the microorganism itself--in pellet form or grown on carriers--which can be supplied with nutrients by spraying in substrate solutions. The colorants and/or active compounds are isolated by extraction with organic solvents.

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Hanover, Germany

Thomas Bayer