4Sc Ag

Bayer Schering Pharma Ag

Altana Pharma Ag

Nycomed Gmbh

Thomas Baer

Thomas Beckers

Thomas Maier

Camille Georges Wermuth

Matthias Vennemann

Petra Gimmnich

Mathias Schmidt

Klaus Pekari

Frank Dullweber

Thomas Ciossek

Gudrun Groegor

Armin Zuelch

Astrid Zimmermann

Volker Gekeler

Rolf-Peter Hummel

Josef Stadlwieser

Ulrich Graedler

Hemant Joshi

Paola Ciapetti

Jean-Marie Contreras

Björn Bartels

Jürgen Braunger

Uday Joshi

Siegfried Schneider

Heike Rothfels

Mahindra Makhija

Bjoern Bartels

Dipak Harel

Kamlesh Padiya

Juergen Braunger

Matthias Mueller

Astrid Leja

Petra Dr Gimmnich

Gianluca Quintini

Compounds of a certain formula (I), in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description, are novel effective HDAC inhibitors. 

Sulfonylpyrroles

The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases. 

Tetrahydro-fused pyridines as histone deacetylase inhibitors

Sulphonylpyrroles

Compounds of a certain formula I, in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity.

Benzothienopyridines for use as inhibitors of Eg5 kinesin

The invention relates to novel pyrimidine derivatives of Formula (1) which are efficacious inhibitors of protein kinases, in particular of one or more isoforms of the protein kinase B/Akt.

4,6-disubstituted pyrimidines and their use as protein kinase inhibitors

Compounds of the formula I in which the substitutents have the definitions provided in the specification, are novel, effective HDAC inhibitors.

Compounds of a certain formula (I), in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

Tetrahydropyridothiophenes

Compounds of a certain formula I in which R1, R2, R3 and R4 have the meanings indicated in the description are novel compounds expected to be useful in the therapy of (hyper)proliferative diseases and/or disorders responsive to induction of apoptosis.

Pyrazolo[1,5-c]pyrimidines

Compounds of a certain formula (I) in which Ra and Rb have the meanings indicated in the description, are novel, effective compounds with anti-proliferative and/or apoptosis inducing activity.

Compounds of the formula (1) in which R1, R2, R3, R4 and X have the meanings indicated in the description, are novel effective compounds with Eg5 inhibitory, anti-proliferative and/or apoptosis inducing activity.

The compounds of a certain formula (1) in which Ra and Rb have the meanings indicated in the description are novel for treating hyperproliferative diseases and/or disorders responsive to the induction of apoptosis. The invention further relates to certain compounds of formula (I), in which Ra and Rb have the meanings indicated in the description.

Compounds and use of tetrahydropyridothiophenes

Compounds of the formula (I) in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and/or apoptosis inducing activity.

Tetrahydropyridothiophenes for use in the treatment of cancer

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Reichenau, Germany

Thomas Baer