Ambu A/s

H. Lundbeck A/s

Vanderbilt University

Coloplast A/s

Phytera Incorporated

Thomas Bachgaard Jensen

Kaspar Mat Matthison-Hansen

Jakob Bønnelykke Kristensen

Karsten Juhl

Mauro Marigo

Lena Tagmose

Søren Christensen

Lone Helboe

Laurent David

Lars Østergaard Pedersen

Jan Torleif Pedersen

Nina Helen Rosenqvist

Christiane Volbracht

Morten Dahl Sørensen

Morten Jacobsen

Kristian Kjaergaard

Jacob Nielsen

Mikkel Jessing

Morten Sørensen

Michael Kappler Hansen

Peer Hoffmann

Justus Claus Alfred Daechsel

Thomas Andersen

Abdur-Rasheed Asuni

Christopher Richard Jones

Craig William Lindsley

P Jeffrey Conn

Darren W Engers

Mikkel Fog Jacobsen

Kayla J Temple

Finn Sonnenborg

Troels Nicolaj Qvist

Madeline Long

Ayodeji Abdur-Rasheed Asuni

Alison R Gregro

Logan A Baker

Kaspar Matthison-Hansen

Justus Claus Daechsel

Anna E Ringuette

Wanwan Yu

David Rodriguez Diaz

Jan Guldberg Hansen

Lasse Kjeld Gjøske Petersen

Angela M Stafford

Günter Wilhelm Schütz

Sebastien Seguy

James Bruce McAlpine

Hans Jochumsen

Jakob Boennelykke Kristensen

Kristian Kjærgaard

Rung De Lin

Sunil Ratnayake

Flemming R Jensen

Wai-Lam Alex Chu

Jack B Jiang

Catharine Noble

Alexandra M SantAna-S&oslash;rensen

Birgitte S&oslash;kilde

Helga Künzl

Henrik Daver

Lars ØStergaard Pedersen

Lone Helbo

An endoscope including at least one operating element, a steerable deflecting element located at the distal end, an endoscope tip, and a steering wire having a first portion, a second portion and an intermediate portion, wherein the intermediate portion is attached to the deflecting element or to the endoscope tip, operation of the at least one operating element to apply a drag force to the first portion moving the endoscope tip in a first direction, and operation of the at least one operating element or another operating element to apply a drag force to the second portion moves the endoscope tip in a second direction different from the first direction, and/or wherein the intermediate portion of the steering tie element is at least in part received in a clearance provided at/in a distal end portion of the deflecting element and/or at/in the endoscope tip.

Endoscope with enhanced steering wire arrangement

A medical device operable to obtain images of an internal cavity of a patient, including a handle; a flexible tube including a first section having a first radial cross-section area and a second section distal of the first section and having a second radial cross-section area smaller than the first radial cross-section area, the second section having an outer surface; a bending section extending from the flexible tube and including a proximal end segment, a distal end segment, and intermediate segments between the proximal end segment and the distal end segment, the intermediate segments hingedly connected to each other, the proximal end segment including a proximal end segment peripheral wall defining an internal space, wherein the second section is positioned at least partly in the internal space; and a camera assembly supported by the bending section and operable to generate images of distal views.

Articulated tip part for an endoscope

A tip part for an endoscope has a vision receptor having a vision sensor for providing an image from received light, a first lens, and a casing, the casing supporting the first lens so that the casing substantially maintains a position of the first lens in relation to the vision sensor; a first light source; an exterior housing; and a light shield positioned between the vision receptor and the first light source so as to prevent ingress of stray light from the first light source into the vision receptor by optically shielding the vision receptor; wherein the casing is formed integrally with the exterior housing so that the casing also substantially maintains the first lens in a position in relation to the exterior housing.

Method of making a tip part for an endoscope

Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine, i.e. 7-(4-((phenyl or pyridin-3-yl)oxy)piperidin-1-yl)-4H-pyrimido[1,2-b]pyridazin-4-one derivatives of formula (I) which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M(mAChR M). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Substituted pyrimido[1,2-b]pyridazines as positive allosteric modulators of the muscarinic acetylcholine receptor M4

A video endoscope including an operating handle; an insertion tube extending distally from the operating handle; a camera at the distal end of the insertion tube; a working channel extending from the housing to the distal end of the insertion tube; and control cables; the operating handle including: a housing; a control lever comprising a wall and trunnions extending laterally from the wall; a first wall comprising a first support aperture; a second wall comprising a second support aperture, the first support aperture and the second support aperture receiving the trunnions to facilitate rotation of the control lever; a sealed compartment; and lateral grooves configured to receive guiding cables.

Endoscope

The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and other tauopathies.

Antibodies specific for hyperphosphorylated tau and methods of use thereof

A tip part for an insertable vision device, and an insertable vision device including the tip part. The tip part includes a housing accommodating an electronic vision receptor and adapted to extend from a distal end of an insertable elongate portion of the insertable vision device, and a light guide positioned within the housing, the light guide having a predetermined length in a longitudinal direction between a light reception end and a light emission end, the light reception end configured to receive light emanated from a light source and the light emission end configured to emit the light. The light guide includes, along at least a portion of the predetermined length, an expanding sector or a narrowing sector.

Tip part for a vision device

An endoscope tip part for an endoscope for visually inspecting inaccessible places, including a tip housing enclosing a sealed interior space and including a transparent portion; an image sensor viewing in an optical direction through the transparent portion of the tip housing; a light guide component having a light entry surface and a light exit surface; a first light source having a light-emitting surface and being configured to emit light from the light-emitting surface in a central illumination direction; and an electrical circuit in electrical communication with the image sensor and the first light source, wherein the first light source, the image sensor, and the electrical circuit are accommodated in the sealed interior space of the tip housing, wherein the first light source is attached to the light guide component.

Endoscope tip part

A medical device operable to obtain images of an internal cavity of a patient, including a handle; a flexible tube; a front end cap housing a camera assembly; a bending section extending from the flexible tube and including a proximal end segment and a distal end segment; a peripheral wall having an inner surface defining an internal space and including a cavity extending radially outwardly from the inner surface; a member having an outer surface and positioned at least partly in the internal space with the cavity overlapping the outer surface; and a protrusion of a hardened adhesive bonded to the outer surface of the member and extending into the cavity of the peripheral wall, wherein the member is one of, and the peripheral wall is comprised by another of, the flexible tube, the proximal end segment, the distal end segment, or the front end cap.

The present invention is directed to compounds of formula I The compounds are considered useful for the treatment of diseases associated with LRRK2 such as Parkinson's disease.

LRRK2 inhibitors

The present invention is directed to compounds of formula IIa These compounds are considered useful for the treatment of diseases associated with leucine-rich repeat kinase 2 (LRRK2) such as Parkinson's disease. Furthermore, the invention relates to pharmaceutical compositions comprising said compounds.

Leucine-rich repeat kinase 2 (LRRK2) inhibitors

Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1 -yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M(mAChR M). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

Substituted pyrimido[1,2-b]pyridazines as positive allosteric modulators of the muscarinic acetylcholine receptor M

Growing community of inventors

Copenhagen, Denmark

Thomas Bachgaard Jensen