Hoffmann-la Roche Inc.

Thomas B Tschopp

Hans Peter Wessel

Gerard Schmid

Jean Ackermann

Kurt Hilpert

David Banner

Beat Wirz

Paul Hadvary

Klaus Gubernator

Ludvik Labler

Niggi Iberg

Klaus Muller

Hans P Marki

Michael Pech

Marianne Rouge

Rita Muller

Jurgen Fingerle

Alexander Chucholowski

G Erard Schmid

Klaus M Uller

Markus Hosang

Michel Trumtel

Compounds of the formula ##STR1## wherein n.sup.1 -n.sup.9 are each independently 0 or 1;

Sulfuric acid esters of sugar alcohols

Compounds of formulas ##STR1## wherein, B is lower alkylene or an optionally substituted aromatic ring system;

Sulfuric acid esters of amino sugars

Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.

Guanidine derivatives

The present invention is concerned with novel sulfuric acid esters of sugar alcohols and sugar alcohol-like compounds of the formula ##STR1## Also described are methods for the treatment and/or prophylaxis of arteriosclerotic changes in the vascular wall as well as a process for the manufacture of the compounds of formula I and their salts.

The use of compounds of the formula ##STR1## wherein R is hydrogen or a residue --SO.sub.3 M; M is a cation; and R' and R' are hydrogen or an .alpha.-glycosidically linked sulfated mono- or disaccharide residue; and at least one --SO.sub.3 M group is present per monosaccharide unit, as pharmaceutical compositions for the prevention and/or treatment of arteriosclerotic disorders and for the prevention of restenosis after invasive vascular surgery and after organ transplants.

Sulfated oligosaccharides

Sulphated O-Polysaccharide-trehaloses which can be used as medicaments, especially for the treatment of arteriosclerotic disorders.

Sulfated O-polysaccharide-trehaloses

Guanidine derivatives compositions and use

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Ettingen, Switzerland

Thomas B Tschopp