Life Technologies Corporation

Danisco US Inc.

Genencor International, Inc.

Thomas B Morrison

Tanya S Kanigan

Volker Schellenberger

John R Linton

Katherine D Collier

Olga V Selifonova

Robert A Hess

Colin J H Brenan

Karl Yoder

Colin Brenan

Arrin Katz

Javier Garcia

Edwin Lee

Nicholas Leiva

Kristine Friesen

Robert Harold Ellis

Adam C Kean

Lance P Encell

Aldis Darzins

Leila Marcia Madrone

Thomas Wessel

Maria R Diaz-Torres

Leila Hasan

Jamie Cho

Beat O Blattmann

John M Davis

Gregory T Mrachko

Eric Van Helen

Howard Weiss

Edwin W Lee

One aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a conductive member for heating the interior volume. Another aspect of the invention provides container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a plurality of conductive members for heating an interior volume. Another aspect of the invention provides a container for thermal cycling a plurality of samples in a microfluidic array. The container includes a plurality of walls defining an interior volume and a first conductive member located in the interior volume and adapted to contact a first end of the microfluidic array.

Devices and methods for thermally-mediated chemical reactions

A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers, at least one of which is light transmissive, of which pair a light transmissive cover forms a top, and of which pair the other forms a bottom. A frame is disposed between the covers to define, in relation to the covers, an interior volume. The frame and the covers are associated with one another to form a case, the case being substantially tight to liquids. A microfluidic array is disposed in the interior volume. The array includes a sheet of material having a pair of opposed surfaces, a thickness, and a plurality of through-holes running through the thickness between the surfaces, the through-holes containing at least one of sample and reagent.

Thermal cycling apparatus and method

Thermal cycling assay apparatus and method

An evolvable production strain ofexhibiting continuous or high level expression during protein evolution is described. An evolvedpstS promoter facilitates screening and production of secreted proteins.

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Cells producing mutant phytases having modified activity are provided, as well as the phytases so produced. Also provided are methods of making and producing such phytases and the use of the expressed phytase protein in feed as a supplement.

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Winchester, MA, United States of America

Thomas B Morrison