Fisons Ltd.

Thomas B Lee

John R Bantick

David N Hardern

Hugh Cairns

Joachim Augstein

Albert Chambers

John Fuher

David Carter

John King

Richard Hazard

There are described compounds of formula I, ##STR1## in which Ra, Rb, Rc, Rd, Re, Rf and Rg, which may be the same or different, each represent hydrogen, amino, hydroxy, alkoxy, alkenyloxy, halogen, acyl, alkenyl, alkyl, or alkoxy substituted by phenyl,

Naphthalene and 2-oxo-benzopyran acids and derivatives and

Compounds

There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.

5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid

There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable organic cation, the salt having a solubility of less than 31 w/w in water a 20.5.degree. C. There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.

The present invention relates to salts with basic amino sugars or basic amino acids of certain 2-carboxy or 2-tetrazolo-chromones.

Basic amino acid salts of chromones

There are provided compounds of formula I, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.7 may be the same or different, and are hydrogen, hydroxy, alkoxy, alkoxy substituted by phenyl, acyl, amino, acylamino, alkenyl, halogen, or alkyl, provided that at least one of R.sup.1, R.sup.2, R.sup.3 and R.sup.7 are other than hydrogen and hydroxy,

2(5-Tetrazolyl)chromones

There are described certain mono-chromone-2-carboxylic acids of formula, ##STR1## having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.

6,8-Di-t-butyl-4-oxo-4H-1-benzopyran-2-carboxylic acid and derivative

There are provided processes for preparing compounds of the formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, and

Pharmaceutical compositions containing 4-carboxy-flavones

Chemical compounds

There are described certain mono-chromone-2-carboxylic acids of formula, ##SPC1## Having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmacetuical compositions, for the treatment of asthma, containing the compounds.

Benzopyran-2-carboxylic acids in the prevention of asthmatic symptoms

There are provided compounds of the formula: ##SPC1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, and X represents a hydrocarbon chain containing from 2 to 10 carbon atoms, optionally substituted by a hydroxy group) and pharmaceutically acceptable derivatives thereof. The compounds are antagonists of the slow reacting substance of anaphylaxis.

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Loughborough, United Kingdom

Thomas B Lee