Astrazeneca Ab

Astra Aktiebolag

Thomas Antonsson

David Gustafsson

Jan-Erik Nystr&ouml;m

Kurt-Jürgen Hoffmann

Jan-Erik Nyström

Kurt-J&uuml;rgen Hoffmann

Mikael Sell&eacute;n

Henrik Sörensen

Henrik S&ouml;rensen

Mikael Sellén

There is provided compounds of formula I,RO(O)C&#x2014;CH&#x2014;(R)Cgl-Aze-Pab-RIwherein Rand Rhave meanings given in the description, which are useful as prodrugs of inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (eg thrombosis) or as anticoagulants.

Prodrugs of thrombin inhibitors

There is provided compounds of formula I, wherein R, R, R, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Amidino derivatives and their use as thrombin inhibitors

There is provided compounds of formula I,

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Lindome, Sweden

Thomas Antonsson