William Marsh Rice University

Baylor College of Medicine

The University of Texas System

The United States Government

Houston Methodist Research Institute

Indiana University

Thomas Andrew Kent

James Mitchell Tour

Jacob Berlin

Ashley Leonard

David P Huston

William Sikkema

Robia G Pautler

Pavana Dixit Hegde

Joy Mitra

Sankar Mitra

Kimberly Mendoza

William Dalmeida, Jr

Prakash Dharmalingam

Paul J Derry

Brittany Bitner

Ah-Lim Tsai

Lizanne Nilewski

Daniela Marcano

Taeko Inoue

Muralidhar L Hegde

Kenneth R Olson

Anton V Liopo

Emily M Mchugh

Mansoor Kahn

Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.

Acute and chronic mitochondrial electron transport chain dysfunction treatments and graphenic materials for use thereof

In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.

Use of carbon nanomaterials with antioxidant properties to treat oxidative stress

Growing community of inventors

Houston, TX, United States of America

Thomas Andrew Kent