Ifirst Medical Technologies, Inc.

Oceanit Laboratories, Inc.

Thomas Alan Hasling

Luke B Joseph

A handheld medical analyzer works with different disposable application cartridges to perform a variety of interrogations on specimen samples. One application includes attaching a biological microelectromechanical systems (BioMEMS) cartridge that generates blood coagulation profiles indicative of particular forms of coagulation disorders. The device makes coagulopathy testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and permits for a larger number of parallel or serial devices operating simultaneously. One insertion of a cartridge actuates an oscillating circular motion to generate a blood coagulation profile based on a change in rotational motion as blood coagulates in a sample. Change in rotational motion is analyzed through a video camera such as in a smartphone and is plotted to show an amplitude over time. Actuation of the BioMEMS can be achieved by magnetic actuation of a motor controlled by an iPhone or a smart phone to provide a specific rotational pattern.

Disposable BioMEMS coagulation profiling cartridge with a tracked oscillating disc

A medical analyzer and coagulation profiler performs various interrogations on specimens. A motor with reduction gearing moves and a video camera observes the samples, the cartridges or parts thereof. Changes in images are compared and recorded with a central processor that controls a display. Power supply, temperature controller, motor and gearing are mounted in a box which attaches to a smartphone. The smartphone provides the video camera, illumination and central processor that control the movement, temperature and display. The device makes testing simpler for small hospitals, clinics, ambulances, remote locations and individuals and controls a number of parallel or serial devices operating simultaneously or sequentially. A cartridge insertion actuates a circular motion to generate a blood profile based on changes. Change is analyzed with a video camera and processor such as in a smartphone and is plotted to show an amplitude and time. A smartphone provides a specific movement pattern.

Medical analyzer and coagulation profiler with tracked oscillating disc

Method of using disposable BioMEMS coagulation profiling cartridge

Medical analyzer and coagulation profiler

Methods of measuring coagulation of a biological sample

Rotating magnetic disc medical analyzer and coagulation profiler

Wave energy is directed into a body. A condition within the body is observed by reflection from effects within the body. An internal target is located. Wave energy is focused on the target within the body and is increased in intensity to treat the target. A hand held instrument passivates or moves scalp from a skull, and converges, diverges or collimates near infrared laser beams through a skull and into interior tissue. Reflected energy reveals vessels edema or bleeding. Vessel targets are identified. Infrared laser beams are directed, triggered and intensified to coagulate or constrict the vessel. The hand held instrument is a wand connected to a laser source, processor, display and power source. The power supply, processor, infrared laser, display and laser director are mounted on a hand held unit for field use by technicians and medics to prevent time delay and further injury.

Laser treatment of body injuries and defects

A first set of carbon nanotubes is functionalized with streptavidin and co-functionalized with a cell treatment payload material. A second set of carbon nanotubes is functionalized with biotin and co-functionalized with specific cell targeting material. Mixing the first and second sets causes four carbon nanotubes from the second set to attach to each carbon nanotube from the first set. Multiple replicated virus-like particles result. The pharmaceutical composition seeks out and attaches to target cells. The carbon nanotubes from the first set penetrate the targeted cells and deliver their cell treatment payloads into the targeted cells. Near infrared energy is transmitted through tissue heating the carbon nanotubes for targeted cell treatment.

Nano-vector prodrug delivery system

Illumination sources are connected to ends of micropipette probes having total internal reflection tips. The total internal reflection produces evanescence at the tips. The evanescence causes fluorescence of dye marked target molecules at tips of the probes. The evanescence is limited to about 100 nm from the tips. The presence of a target molecule at the end of a probe is observed by observing the fluorescence. The limited penetration of the evanescence eliminates noise in the signal and unwanted bleaching of dyes in the cell, so that repeated, multiple and arrays of probes may be applied.

Growing community of inventors

Honolulu, HI, United States of America

Thomas Alan Hasling